1442679-99-3

Basic information

• Product Name: C₄₉H₄₅ClN₂O₆
• Synonyms: C₄₉H₄₅ClN₂O₆
• CAS NO: 1442679-99-3
• Molecular Weight: 793.359
• Mol File: 1442679-99-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₄₉H₄₅ClN₂O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₄₉H₄₅ClN₂O₆(1442679-99-3)
• EPA Substance Registry System: C₄₉H₄₅ClN₂O₆(1442679-99-3)

Safety Data

• Hazardous Substances Data: 1442679-99-3(Hazardous Substances Data)

Upstream product

• 1442679-60-8 (2R,3S,4R)-3,4-bis((4-methoxybenzyl)oxy)-2-((trityloxy)methyl)-3,4-dihydro-2H-pyran-5-carbaldehyde 
• 19563-04-3 p-chlorobenzamidine 
• 1442679-71-1 3,4-di-O-(p-methoxybenzyl)-6-O-trityl-D-glucal 
• 122350-80-5 1,5-anhydro-2-deoxy-6-O-trityl-D-arabino-hex-1-enitol 
• 13265-84-4 D-glucal 
• 76-83-5 trityl chloride 
• 1442681-53-9 3,4-di-O-(p-methoxybenzyl)-6-O-trityl-D-galactal 
• 122350-80-5 2-((trityloxy)methyl)-3,4-dihydro-2H-pyran-3,4-diol 
• 21193-75-9 D-galactal 
• 1442679-74-4 2-C-formyl-3,4-di-O-(p-methoxybenzyl)-6-O-trityl-D-galactal 
• 115297-57-9 4-chlorobenzene-1-carboximidamide hydrogeniodide 

Downstream Products

• 1442680-70-7 C₃₄H₃₄ClN₅O₅ 
• 1442680-80-9 C₃₄H₃₂ClN₅O₆ 
• 1442680-82-1 C₃₅H₃₄ClN₅O₆ 
• 1442681-30-2 C₁₈H₁₈ClN₅O₃ 

Relevant articles and documents

Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay

New antimalarial agents that exhibit multistage activities against drug-resistant strains of malaria parasites represent good starting points for developing next-generation antimalarial therapies. To facilitate the progression of such agents into the development phase, we developed an image-based parasitological screening method for defining drug effects on different asexual life cycle stages of Plasmodium falciparum. High-throughput screening of a newly assembled diversity-oriented synthetic library using this approach led to the identification of carbohybrid-based 2-aminopyrimidine compounds with fast-acting growth inhibitory activities against three laboratory strains of multidrug-resistant P. falciparum. Our structure-activity relationship study led to the identification of two derivatives (8aA and 11aA) as the most promising antimalarial candidates (mean EC50of 0.130 and 0.096 μM against all three P. falciparum strains, selectivity indices >600, microsomal stabilities >80%, and mouse malaria ED50values of 0.32 and 0.12 mg/kg/day, respectively), targeting all major blood stages of multidrug-resistant P. falciparum parasites.