144363-77-9

Basic information

• Product Name: 5-O-benzyl-2,3-di-O-isopropyliden-2-C-methyl-α,β-D-ribose
• CAS NO: 144363-77-9
• Molecular Weight: 294.348
• Mol File: 144363-77-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-O-benzyl-2,3-di-O-isopropyliden-2-C-methyl-α,β-D-ribose(CAS DataBase Reference)
• NIST Chemistry Reference: 5-O-benzyl-2,3-di-O-isopropyliden-2-C-methyl-α,β-D-ribose(144363-77-9)
• EPA Substance Registry System: 5-O-benzyl-2,3-di-O-isopropyliden-2-C-methyl-α,β-D-ribose(144363-77-9)

Safety Data

• Hazardous Substances Data: 144363-77-9(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 23709-41-3 2-methyl-2,3-O-(1-methylethylidene)-D-ribonic acid γ-lactone 
• 144363-76-8 5-O-benzyl-2,3-di-O-isopropyliden-2-C-methylribono-γ-lactone 

Downstream Products

• 144363-87-1 1-(2,3-Di-O-acetyl-5-O-benzyl-2-C-methyl-D-ribofuranosyl)thymine 
• 144363-85-9 6-Chloro-9-(2,3-di-O-acetyl-5-O-benzyl-2-C-methyl-β-D-ribofuranosyl)-9H-purine 
• 144363-78-0 1,2,3-Tri-O-acetyl-5-O-benzyl-2-C-methyl-D-ribofuranose 
• 119410-84-3 2'-C-methylthymidine 
• 15397-12-3 2'-methyl-adenosine 

Relevant articles and documents

2-C-Methyluridine modified hammerhead ribozyme against the estrogen receptor

A new synthesis of 2′-C-methyluridine phosphoramidite is presented. Special emphasis is dedicated to the improvement of the protection of the tertiary 2′-hydroxyl group. Comparison to previous protecting strategies and analysis of stability under 5′-DMTr removing conditions are discussed. The synthetic incorporation of this modified nucleoside into the catalytic core of a hammerhead ribozyme against the estrogen receptor α protein (ER-α), and transfection experiments in MCF-7 cell line are also presented.