144481-98-1 Usage
Uses
Used in Pharmaceutical Industry:
Benzenepropanoic acid,4-[(2S)-2-hydroxy-3-[[2-[(4-morpholinylcarbonyl)amino]ethyl]amino]propoxy]-,[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl ester, hydrochloride (1:1) is used as a pharmaceutical compound for its potential therapeutic applications. The compound's unique structure and functional groups may allow it to interact with specific biological targets, such as receptors or enzymes, which could be beneficial in the treatment of various diseases.
Used in Chemical Research:
In the field of chemical research, this compound can be utilized as a starting material or intermediate for the synthesis of other complex organic molecules. Its versatile structure and functional groups make it a valuable candidate for further modification and exploration in the development of new chemical entities with potential applications in various industries.
Used in Material Science:
The compound's structural features and functional groups may also find applications in material science, where it could be used to develop new materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical processes.
Synthesis
The synthesis of landiolol
appeared in an earlier patent in 1990. Esterification of 3-
(4-hydroxyphenyl)propionic acid (141) with 2,2-dimethyl-
1,3-dioxolan-4-ylmethyl chloride (142) in DMSO gave
desired ester 143 in 57% yield. Treatment of phenol 143
with bromo epoxide 144 in the present of K2CO3 afforded
ether 145 in 76% yield. Epoxide 145 was then reacted with
free amine 146 via a neucleophilic ring opening process to
provide landiolol (14).
Check Digit Verification of cas no
The CAS Registry Mumber 144481-98-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,4,8 and 1 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 144481-98:
(8*1)+(7*4)+(6*4)+(5*4)+(4*8)+(3*1)+(2*9)+(1*8)=141
141 % 10 = 1
So 144481-98-1 is a valid CAS Registry Number.
InChI:InChI=1/C25H39N3O8.ClH/c1-25(2)35-18-22(36-25)17-34-23(30)8-5-19-3-6-21(7-4-19)33-16-20(29)15-26-9-10-27-24(31)28-11-13-32-14-12-28;/h3-4,6-7,20,22,26,29H,5,8-18H2,1-2H3,(H,27,31);1H/t20-,22+;/m0./s1
144481-98-1Relevant articles and documents
Preparation method of landiolol hydrochloride intermediate
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Paragraph 0026, (2021/06/06)
The invention discloses a preparation method of a high-purity landiolol hydrochloride intermediate N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. The preparation method comprises the following steps: reacting N-phenoxy carbonyl morpholine with ethylenediamine, concentrating the reaction liquid, adding a solvent for dissolving, adjusting the pH value to 9-14 by using alkali, filtering to remove solid byproducts, concentrating the filtrate to obtain N-(2-aminoethyl)-4-morpholine formamide, adding water for dissolving, adjusting the pH value to 1-6 by using oxalic acid, filtering to remove a small amount of ethylenediamine oxalate solid, concentrating the filtrate, adding a solvent, and recrystallizing to obtain the high-purity N-(2-aminoethyl)-4-morpholinecarboxamide oxalate. According to the method, the high-purity landiolol hydrochloride intermediate can be obtained, the defects that the byproduct sodium phenate is difficult to filter, ethylenediamine is easy to remain and the like are overcome, the process is stable and controllable, the solvent can be recycled, and the method is more suitable for industrial production.
Method for preparing landiolol hydrochloride
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, (2019/12/02)
The invention belongs to the field of pharmaceutical chemicals, and particularly relates to an improved method for preparing landiolol and a compound shown as a formula 8. The compound shown as the formula 8 is prepared by reacting a compound shown as a formula 7 with AH (organic amine). The invention also relates to compounds of general formula 7.
Process for the enantioselective synthesis of landiolol
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, (2018/06/28)
PROBLEM TO BE SOLVED: To provide a process for the enantioselective synthesis of landiolol.SOLUTION: The process for the enantioselective synthesis of landiolol represented by formula (B) uses a compound represented by formula (A) as an intermediate.