1445076-24-3

Basic information

• Product Name: (E)-methyl 2-(4-(3,3-diisopropyltriaz-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate
• Synonyms: (E)-methyl 2-(4-(3,3-diisopropyltriaz-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate
• CAS NO: 1445076-24-3
• Molecular Weight: 381.346
• Mol File: 1445076-24-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-methyl 2-(4-(3,3-diisopropyltriaz-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-methyl 2-(4-(3,3-diisopropyltriaz-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate(1445076-24-3)
• EPA Substance Registry System: (E)-methyl 2-(4-(3,3-diisopropyltriaz-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate(1445076-24-3)

Safety Data

• Hazardous Substances Data: 1445076-24-3(Hazardous Substances Data)

Upstream product

• 348-54-9 2-Fluoroaniline 
• 108-18-9 diisopropylamine 
• 392-41-6 methyl trifluoropropenoate 
• 1445077-36-0 (E)-1-(2-fluorophenyl)-3,3-diisopropyltriaz-1-ene 

Downstream Products

• 1445076-52-7 methyl 2-(4-azido-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate 
• 1445076-56-1 methyl 2-(4-(cyclopent-1-en-1-yl)-3-fluorophenyl)-2,3,3,3-tetrafluoropropanoate 

Relevant articles and documents

Silver-mediated methoxycarbonyltetrafluoroethylation of arenes

In the presence of silver(I) fluoride, highly fluorinated olefins react readily under solvent-free conditions with arenes via CH-substitution. This transformation could be used to synthesize various methoxycarbonyltetrafluoroethylated aromatic triazenes and anisoles under high functional group tolerance. The method could be applied to the synthesis of a formal fluorinated bioisostere of the NSAID flurbiprofen. To the best of our knowledge, this is the first example which uses highly fluorinated olefins for the perfluoroalkylation of aromatic substrates.