1445085-82-4

Basic information

• Product Name: SPhos Pd G3
• Synonyms: Methanesulfonato(2-dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II) dichloroMethane adduct, Min. 98% [SPhos Palladacycle];Methanesulfonato(2-dicyclohexylphosphino-2',6'-diMethoxy-1,1'-biphenyl)(2'-aMino-1,1'-biphenyl-2-yl)palladiuM(II) dichloroMethane adduct, Min. 98%;(2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl) [2-(2'-amino-1,1'-biphenyl)]palladium(II) methanesulfonate;Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II)dichloromethane adduct;[2'-(Amino)[1,1'-biphenyl]-2-yl][dicyclohexyl(2',6'-dimethoxy[1,1'-biphenyl]-2-yl)phosphine](methanesulfonato)palladium;Methanesulfonato(2-dicyclohexylphosphino-2',6'-dimethoxy-1,1'-biphenyl)(2'-amino-1,1'-biphenyl-2-yl)palladium(II) dichloromethane adduct OMS-SPhos;SPhos Pd G3 97%;SPhos Palladacycle Gen.3
• CAS NO: 1445085-82-4
• Molecular Formula: C₁₃H₁₃NO₃PdS*C₂₆H₃₅O₂P
• Molecular Weight: 866.201401
• Product Categories: Buchwald Ligands&Precatalysts;Buchwald Precatalysts Series;Pd
• Mol File: 1445085-82-4.mol
• Article Data: 1

Chemical Properties

• Appearance: pale yellow/solid
• Storage Temp.: 2-8°C
• CAS DataBase Reference: SPhos Pd G3(CAS DataBase Reference)
• NIST Chemistry Reference: SPhos Pd G3(1445085-82-4)
• EPA Substance Registry System: SPhos Pd G3(1445085-82-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1445085-82-4(Hazardous Substances Data)

Usage

Description

SPhos Pd G3, also known as a stable phosphine-ligated palladium precatalyst, is a chemical compound that plays a crucial role in various chemical reactions. It is specifically designed to facilitate the formation of carbon-carbon (C-C) and carbon-nitrogen (C-N) bonds, which are essential in the synthesis of numerous organic compounds and materials.

Uses

Used in Chemical Synthesis:
SPhos Pd G3 is used as a catalyst for the formation of C-C and C-N bonds in chemical synthesis. Its application reason is to enhance the efficiency and selectivity of these bond-forming reactions, leading to the production of desired organic compounds with minimal side reactions or byproducts.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, SPhos Pd G3 is used as a catalyst for the synthesis of complex drug molecules. Its application reason is to facilitate the formation of essential C-C and C-N bonds, enabling the production of a wide range of therapeutic agents with improved efficiency and reduced environmental impact.
Used in Material Science:
In the field of material science, SPhos Pd G3 is used as a catalyst for the development of advanced materials with specific properties. Its application reason is to promote the formation of C-C and C-N bonds in the synthesis of novel polymers, nanoparticles, and other materials with potential applications in various industries, such as electronics, energy storage, and environmental protection.
Used in Agrochemical Industry:
In the agrochemical industry, SPhos Pd G3 is used as a catalyst for the synthesis of various agrochemicals, including pesticides and fertilizers. Its application reason is to improve the efficiency of C-C and C-N bond formation, leading to the development of more effective and environmentally friendly products for agricultural use.

Reactions

Palladium precatalyst for the arylation of amines.

Upstream product

• 90-41-5 2-phenylaniline 
• 1445085-50-6 [1,1'-biphenyl]-2-aminium methanesulfonate 
• 657408-07-6 dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane 
• 1435520-65-2 (2'-amino-1,1'-biphenyl-2-yl)methanesulfonatopalladium(II) dimer 

Relevant articles and documents

Design and preparation of new palladium precatalysts for C-C and C-N cross-coupling reactions

A series of easily prepared, phosphine-ligated palladium precatalysts based on the 2-aminobiphenyl scaffold have been prepared. The role of the precatalyst-associated labile halide (or pseudohalide) in the formation and stability of the palladacycle has been examined. It was found that replacing the chloride in the previous version of the precatalyst with a mesylate leads to a new class of precatalysts with improved solution stability and that are readily prepared from a wider range of phosphine ligands. The differences between the previous version of precatalyst and that reported here are explored. In addition, the reactivity of the latter is examined in a range of C-C and C-N bond forming reactions.