144541-45-7

Basic information

• Product Name: methyl (2S,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate
• Synonyms: Methyl (2S,3S)-n-benzoyl-3-phenylisoserin hcl;METHYL (2S,3S)-N-BENZOYL-3-PHENYLISOSERIN HYDROCHLORIDE;Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, methyl ester, (αS,βS)-
• CAS NO: 144541-45-7
• Molecular Formula: C₁₇H₁₇NO₄
• Molecular Weight: 299.3212
• Mol File: 144541-45-7.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 540.315°C at 760 mmHg
• Flash Point: 280.572°C
• Density: 1.236g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.588
• PKA: 12.05±0.20(Predicted)
• CAS DataBase Reference: methyl (2S,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl (2S,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate(144541-45-7)
• EPA Substance Registry System: methyl (2S,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate(144541-45-7)

Safety Data

• Hazardous Substances Data: 144541-45-7(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 131968-73-5 Chloro-acetic acid (3S,4R)-1-benzoyl-2-oxo-4-phenyl-azetidin-3-yl ester 
• 131968-74-6 (2R,3S)-3-Amino-2-hydroxy-3-phenyl-propionic acid methyl ester 
• 98-88-4 benzoyl chloride 
• 780721-69-9 3-Amino-2-hydroxy-3-phenyl-propionic acid methyl ester 
• 55325-49-0 (±)-anti-3-amino-2-hydroxy-3-phenylpropanamide 
• 140196-38-9 1,1-dimethyl (2-oxo-1-phenylethyl)carbamate 
• 161060-38-4 [2-Hydroxy-2-(4-isopropyl-5-oxo-2,5-dihydro-oxazol-2-yl)-1-phenyl-ethyl]-carbamic acid tert-butyl ester 
• 161167-76-6 2-(3-tert-Butoxycarbonylamino-2-hydroxy-3-phenyl-propionylamino)-3-methyl-butyric acid methyl ester 
• 55325-49-0 (2RS,3SR)-3-Phenylisoserinamide 
• 94612-33-6 1-(4-methoxyphenyl)-4-phenylazetidine-2,3-dione 
• 131968-72-4 Chloro-acetic acid (3S,4R)-2-oxo-4-phenyl-azetidin-3-yl ester 
• 101067-78-1 (+/-)-(3R,4S)-3-hydroxy-4-phenyl-N-(4-methoxyphenyl)azetidin-2-one 
• 7309-55-9 N-benzoyl-(2R^*,3S^*)-3-phenylisoserine 

Downstream Products

• 146848-91-1 (4S,5R)-2,4-diphenyl-2-oxazoline-5-carboxylic acid methyl ester 
• 32981-85-4 methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate 
• 7309-55-9 N-benzoyl-(2R^*,3S^*)-3-phenylisoserine 
• 132201-33-3 (2R,3S)-N-benzoyl-3-phenylisoserine 

Relevant articles and documents

Synthesis method of paclitaxel side chain and analogs thereof (by machine translation)

The invention discloses a synthesis method of a taxol side chain ((4S, 5R) -3 - benzoyl -2 - (4 - methoxyphenyl) -4 - phenyl -5 - oxazoline carboxylic acid) shown as a formula (f) and a series of reactions such as epoxidation, methyl esterification, ammonolysis, ester hydrolysis, condensation, configuration overturning, condensation and hydrolysis as well as analogues thereof. The invention discloses a synthesis method of the taxol side chain ((4S 5R) -3 -benzoyl -2 - (4 - methoxyphenyl) -4 - phenyl -5 - oxazoline carboxylic acid) and the like. The method has the advantages of short reaction time, high yield, good chiral selectivity, suitability for industrial production and the like. (by machine translation)

Method for preparing optically active alpha-hydroxy-beta-amino acid compounds

The invention discloses a method for preparing optically active N-acyl-beta-hydroxy-amino ester compounds of formula II from alpha-acyloxy-beta-enamine ester compounds through a one-pot process. The method uses novel six-membered cyclic pyridinecarboxamid

Efficient enantioselective synthesis of α-hydroxy-β-amino acids using the Claisen and Curtius rearrangements

Highly enantioselective and facile synthesis of α-hydroxy-β- amino acids has been achieved using the Claisen and Curtius rearrangements as key reactions. Chiral allylic alcohols were employed, which can be prepared by asymmetric catalysis in both E- and Z