144603-83-8 Usage
Description
(3R)-3-chloro-3-fluoroquinoline-2,4(1H,3H)-dione is a quinoline-2,4-dione derivative with the molecular formula C9H5ClFNO2. It features both chlorine and fluorine substituents and is an important intermediate in the synthesis of various pharmaceuticals and agrochemicals. This chemical compound has been studied for its antimicrobial, antifungal, and antineoplastic properties, making it a valuable building block for the development of new drugs and agricultural chemicals.
Uses
Used in Pharmaceutical Industry:
(3R)-3-chloro-3-fluoroquinoline-2,4(1H,3H)-dione is used as an intermediate in the synthesis of various pharmaceuticals for its potential antimicrobial, antifungal, and antineoplastic properties. Its unique structure and functional groups contribute to the development of new drugs with enhanced therapeutic effects.
Used in Agrochemical Industry:
(3R)-3-chloro-3-fluoroquinoline-2,4(1H,3H)-dione is used as an intermediate in the synthesis of various agrochemicals, where it can be utilized to develop new pesticides or fungicides with improved efficacy. Its antimicrobial properties can be harnessed to protect crops from diseases and pests, thereby increasing agricultural productivity.
Check Digit Verification of cas no
The CAS Registry Mumber 144603-83-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,0 and 3 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 144603-83:
(8*1)+(7*4)+(6*4)+(5*6)+(4*0)+(3*3)+(2*8)+(1*3)=118
118 % 10 = 8
So 144603-83-8 is a valid CAS Registry Number.
144603-83-8Relevant articles and documents
Halogenation Reactions in Position 3 of Quinoline-2,4-dione Systems by Electrophilic Substitution and Halogen Exchange
Stadlbauer, Wolfgang,Laschober, Rita,Lutschounig, Herbert,Schindler, Gerda,Kappe, Thomas
, p. 617 - 636 (2007/10/02)
3-Substituted 4-hydroxy-2(1H)-quinolones 3, 5, 7 are halogenated with bromine or sulfuryl chloride to yield the quinolinediones 9 or 10.Reactions of 3, 5, 7 with chloroform gives the dichloromethyl quinolinediones 11.Halogen exchange leads from the chloro quinolinediones 10 to fluoro quinolinedones 12 and to azido quinolinediones 13.Similarly the dichloro quinolinediones 10an reacts to the difluoro quinolinedione 14, which is reduced to the 3-fluoro-4-hydroxyquinolone 16 and reacts again with sulfuryl chloride to give the mixed 3-chloro-3-fluoroquinolinedione 15.Keywords.Fluorination; 4-Hydroxy-2(1H)-quinolones, 3-alkyl/3-aryl/3-fluoro; 1-Hydroxy-benzoquinolizine-3-ones, 2-alkyl/3-aryl; Quinoline-2,4(1H,3H)-diones, 3-azido-3-alkyl/3-aryl, 3-bromo-3-alkyl/3-aryl, 3-chloro-3-alkyl/3-aryl, 3-fluoro-3-alkyl/3-aryl, 3-dichloromethyl-3-alkyl/3-aryl, 3-chloro-3-fluoro.
