144619-46-5 Usage
General Description
(3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione is a chemical compound with the molecular formula C16H8ClFNO2. It is a quinoline-2,4-dione derivative, which is a class of compounds known for their potential pharmacological and biological activities. This particular compound is characterized by the presence of a chlorine atom and a fluorine atom attached to the quinoline ring, as well as a phenyl group. The stereochemistry of the molecule is specified as (3R), indicating the configuration of the chiral center. (3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione may have potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. Further research and study are needed to fully understand the properties and potential uses of (3R)-3-chloro-6-fluoro-3-phenylquinoline-2,4(1H,3H)-dione.
Check Digit Verification of cas no
The CAS Registry Mumber 144619-46-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,4,6,1 and 9 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 144619-46:
(8*1)+(7*4)+(6*4)+(5*6)+(4*1)+(3*9)+(2*4)+(1*6)=135
135 % 10 = 5
So 144619-46-5 is a valid CAS Registry Number.
144619-46-5Relevant articles and documents
Halogenation Reactions in Position 3 of Quinoline-2,4-dione Systems by Electrophilic Substitution and Halogen Exchange
Stadlbauer, Wolfgang,Laschober, Rita,Lutschounig, Herbert,Schindler, Gerda,Kappe, Thomas
, p. 617 - 636 (2007/10/02)
3-Substituted 4-hydroxy-2(1H)-quinolones 3, 5, 7 are halogenated with bromine or sulfuryl chloride to yield the quinolinediones 9 or 10.Reactions of 3, 5, 7 with chloroform gives the dichloromethyl quinolinediones 11.Halogen exchange leads from the chloro quinolinediones 10 to fluoro quinolinedones 12 and to azido quinolinediones 13.Similarly the dichloro quinolinediones 10an reacts to the difluoro quinolinedione 14, which is reduced to the 3-fluoro-4-hydroxyquinolone 16 and reacts again with sulfuryl chloride to give the mixed 3-chloro-3-fluoroquinolinedione 15.Keywords.Fluorination; 4-Hydroxy-2(1H)-quinolones, 3-alkyl/3-aryl/3-fluoro; 1-Hydroxy-benzoquinolizine-3-ones, 2-alkyl/3-aryl; Quinoline-2,4(1H,3H)-diones, 3-azido-3-alkyl/3-aryl, 3-bromo-3-alkyl/3-aryl, 3-chloro-3-alkyl/3-aryl, 3-fluoro-3-alkyl/3-aryl, 3-dichloromethyl-3-alkyl/3-aryl, 3-chloro-3-fluoro.