1446418-91-2

Basic information

• Product Name: 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one
• Synonyms: 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one
• CAS NO: 1446418-91-2
• Molecular Weight: 293.389
• Mol File: 1446418-91-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one(1446418-91-2)
• EPA Substance Registry System: 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one(1446418-91-2)

Safety Data

• Hazardous Substances Data: 1446418-91-2(Hazardous Substances Data)

Upstream product

• 123784-07-6 2-(5-bromothiophen-2-yl)pyridine 
• 10342-83-3 4'-Bromopropiophenone 
• 3319-99-1 2'-(2-thienyl)pyridine 

Relevant articles and documents

Direct heteroarylation of 5-bromothiophen-2-ylpyridine and of 8-bromoquinoline via palladium-catalysed C-H bond activation: Simpler access to heteroarylated nitrogen-based derivatives

The palladium-catalysed direct heteroarylation of the pyridyl-containing substrates, 2-(5-bromothiophen-2-yl)pyridine and 8-bromoquinoline, proceeds in moderate to high yields with a variety of heteroarenes in the presence of 1-2 mol% of a palladium catalyst. This approach allows the access to polyheteroaromatics which are interesting building blocks as (NC)-chelate ligands. The reaction proceeds regioselectively at the C5 position of thiophenes, thiazoles, furans or pyrroles and tolerates various substituents such as formyl, acetyl, ester, nitrile or chloro on the heteroarene. Therefore, this method allows a straightforward modulation of the electron density distribution on such derivatives.