144688-80-2

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester
• CAS NO: 144688-80-2
• Molecular Formula: C13H17NO2
• Molecular Weight: 219.283
• Mol File: 144688-80-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester(144688-80-2)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester(144688-80-2)

Safety Data

• Hazardous Substances Data: 144688-80-2(Hazardous Substances Data)

Usage

General Description

1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester, also known as Phenylmethyl pyrrolidine (PMP), is a chemical compound with the molecular formula C15H21NO2. It is a methyl ester derivative of pyrrolidinecarboxylic acid and is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. PMP is known for its analgesic, antinociceptive, and antidepressant properties, and it also exhibits some dopamine reuptake inhibitory activity. 1-Pyrrolidinecarboxylic acid, 2-(phenylmethyl)-, methyl ester is often used in the research and development of novel therapeutics targeting the central nervous system, and its unique chemical structure makes it a valuable tool in drug discovery and medicinal chemistry.

Upstream product

• 144688-71-1 α-benzyl-α-cyano-N-methoxycarbonylpyrrolidine 
• 250691-28-2 methyl pyrrolidinecarboxylate iminium cation 
• 6921-34-2 benzylmagnesium chloride 
• 855595-94-7 N-methoxycarbonyl-2-trimethylsilylpyrrolidine 
• 100-39-0 benzyl bromide 
• 28493-54-1 benzyltributyltin 
• 56475-80-0 N-(methoxycarbonyl)pyrrolidine 
• 130147-41-0 N-methoxycarbonyl-α-cyanopyrrolidine 
• 56475-88-8 methyl 2-methoxypyrrolidine-1-carboxylate 

Downstream Products

• 56475-88-8 methyl 2-methoxypyrrolidine-1-carboxylate 

Relevant articles and documents

Distannane mediated reaction of N-acyliminium ion pools with alkyl halides. A chain mechanism involving radical addition followed by electron transfer

Hexabutyldistannane was found to be an effective mediator allowing the reaction of N-acyliminium ion pools with alkyl halides. A chain mechanism involving the addition of an alkyl radical generated from an alkyl halide to an N-acyliminium ion followed by the one-electron reduction of the resulting radical-cation by distannane was proposed.

Electrochemical deallylation of α-allyl cyclic amines and synthesis of optically active quaternary cyclic amino acids

Electrochemical oxidation of α-allylated and α-betizylated N-acylated cyclic amines by using a graphite anode easily affords the corresponding α-methoxylated products with up to 76% yield. Ease of oxidation was affected by the type of electrode, the size

Reaction of an electrogenerated 'iminium cation pool' with organometallic reagents. Direct oxidative α-alkylation and -arylation of amine derivatives

We have developed an efficient direct oxidative α-alkylation and -arylation of carbamates based on the 'cation pool' method. Grignard reagents, organozinc compounds, and organoaluminum compounds are effective as carbon nucleophiles toward iminium cation pools generated by low temperature electrolysis of carbamates.