1447-70-7

Basic information

• Product Name: 4-(dibenzo[b,e]thiepin-11(6H)-ylidene)-1-methylpiperidine
• CAS NO: 1447-70-7
• Molecular Formula: C₂₀H₂₁NS
• Molecular Weight: 307.4524
• Mol File: 1447-70-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 465.3°C at 760 mmHg
• Flash Point: 235.2°C
• Density: 1.165g/cm³
• Vapor Pressure: 7.75E-09mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: 4-(dibenzo[b,e]thiepin-11(6H)-ylidene)-1-methylpiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dibenzo[b,e]thiepin-11(6H)-ylidene)-1-methylpiperidine(1447-70-7)
• EPA Substance Registry System: 4-(dibenzo[b,e]thiepin-11(6H)-ylidene)-1-methylpiperidine(1447-70-7)

Safety Data

• Hazardous Substances Data: 1447-70-7(Hazardous Substances Data)

Upstream product

• 1531-82-4 11-(1-methyl-4-piperidyl)-6,11-dihydrodibenzothiepin-11-ol 
• 5570-77-4 4-chloro-1-methylpiperidine 
• 1531-77-7 dibenzo[b,e]thiepin-11(6H)-one 

Relevant articles and documents

Piperidine derivative and pharmaceutical composition containing it

Piperidine derivatives of formula (I) and their pharmaceutically acceptable salts have antihypertensive action. The compounds may be included in pharmaceutical compositions for oral or parenteral administration.

POTENTIAL ANTIDEPRESSANTS: SATURATED SIDE CHAIN AMINES DERIVED FROM 6,11-DIHYDRODIBENZOTHIEPIN AND 4,9-DIHYDROTHIENO-2-BENZORHIEPIN

Reduction of IV with hydroiodic acid afforded almost quantitatively the spirocyclic amino sulfide VII, evidently via V and VI.The carbamate II was chlorinated with N-chlorosuccinimide, the product (XII) was reacted with phenylmagnesium bromide and the reduced with LiAlH4 to give the 6-phenyl derivative X of the antidepressant agent hydrothiadene (I).Treatment of 11-methyl-6,11-dihydrodibenzothiepin (XIII) with butyllithium followed by alkylation with 3-dimethylaminopropyl chloride resulted in 6-(3-dimethylaminopropyl) derivative XIV.Reaction of XIV with ethyl chloroformate and the following alkaline hydrolysis gave the 6-(3-methylaminopropyl) derivative XV (mixture of stereoisomers).Reduction of the corresponding olefinic amine and the tertiary alcohol with hydroiodic acid gave the saturated side chain amines derived from 4,9-dihydrothieno-2-benzothiepin XVIII and XIX.The dihydroderivative of dithiadene XVIII (VUFB-17031) proved very effective in a series of tests predictive of antidepressant activity.