14472-80-1

Basic information

• Product Name: Cyclohexanone, 4-(4-chlorophenyl)-
• Synonyms: Cyclohexanone, 4-(4-chlorophenyl)-;4-(4-chlorophenyl)cyclohexanone;4-(p-Chlorophenyl)cyclohexanone
• CAS NO: 14472-80-1
• Molecular Formula: C₁₂H₁₃ClO
• Molecular Weight: 208.68
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 14472-80-1.mol
• Article Data: 18

Chemical Properties

• Melting Point: 138-141 °C
• Boiling Point: 323.664 °C at 760 mmHg
• Flash Point: 171.767 °C
• Appearance: colorless liquid
• Density: 1.165g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.551
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: Chloroform, Dichloromethane
• CAS DataBase Reference: Cyclohexanone, 4-(4-chlorophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)
• EPA Substance Registry System: Cyclohexanone, 4-(4-chlorophenyl)-(14472-80-1)

Safety Data

• Hazardous Substances Data: 14472-80-1(Hazardous Substances Data)

Usage

Description

Cyclohexanone, 4-(4-chlorophenyl)-, also known as 4-(4-Chlorophenyl)cyclohexanone, is an organic compound with the CAS number 14472-80-1. It is a white solid and is primarily used in organic synthesis due to its unique chemical structure and properties.

Uses

Used in Organic Synthesis:
Cyclohexanone, 4-(4-chlorophenyl)is used as a key intermediate in the synthesis of various organic compounds. Its chemical structure allows for a wide range of reactions, making it a versatile building block in the development of new molecules with potential applications in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Cyclohexanone, 4-(4-chlorophenyl)is used as a starting material for the synthesis of various pharmaceutical compounds. Its unique structure can be modified to create new drugs with specific therapeutic properties, contributing to the development of novel treatments for various diseases.
Used in Chemical Industry:
Cyclohexanone, 4-(4-chlorophenyl)is also used in the chemical industry for the production of various chemicals and materials. Its versatility in organic synthesis makes it a valuable component in the creation of new chemical products, such as plastics, coatings, and adhesives.
Used in Research and Development:
In the field of research and development, Cyclohexanone, 4-(4-chlorophenyl)is utilized as a model compound for studying various chemical reactions and mechanisms. Its unique properties make it an ideal candidate for understanding the behavior of similar compounds and developing new synthetic strategies.

InChI:InChI=1/C12H13ClO/c13-11-5-1-9(2-6-11)10-3-7-12(14)8-4-10/h1-2,5-6,10H,3-4,7-8H2

Upstream product

• 101598-25-8 4-(4-chloro-phenyl)-heptanedioic acid diethyl ester 
• 36716-71-9 4-(4-chlorophenyl)-4-hydroxycyclohexanone 
• 126991-59-1 8-(4-chlorophenyl)-1,4-dioxaspiro[4.5]decan-8-ol 
• 25253-51-4 4-(4-chlorophenyl)cyclohexanone monoehtylene ketal 
• 126991-60-4 4-(4-chlorophenyl)cyclohex-3-enone monoehtylene ketal 
• 4746-97-8 cyclohexanedione monoethylene ketal 
• 637-87-6 1-Chloro-4-iodobenzene 
• 36716-75-3 4-(p-chlorophenyl)-3-cyclohexen-1-one 
• 106-39-8 bromochlorobenzene 
• 1409956-58-6 2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)-3,4-dihydronaphthalen-1(2H)-one 
• 155098-65-0 4-(4-oxocyclohexyl)phenyl trifluoromethanesulfonate 
• 930766-09-9 4-(4-chlorophenyl)cyclohexan-1-ol 
• 873-77-8 (4-chlorphenyl)magnesium bromide 

Downstream Products

• 98322-65-7 4-(4-Chloro-phenyl)-cyclohexanol 
• 868142-04-5 8-(4-chloro-phenyl)-1,3-diaza-spiro[4.5]decane-2,4-dione 
• 887578-35-0 1-amino-4-(4-chloro-phenyl)-cyclohexanecarboxylic acid 
• 868142-29-4 8-(4-chloro-phenyl)-2,4-dioxo-1,3-diaza-spiro[4.5]decane-1,3-dicarboxylic acid di-tert-butyl ester 
• 215672-87-0 Oxalic acid mono-[4-(4-chloro-phenyl)-cyclohexyl] ester 
• 1071223-07-8 cis-2-[4-(4-chlorophenyl)cyclohexyl]-3-chloro-1,4-naphthoquinone 
• 1297474-44-2 C₁₅H₁₁ClN₂OS 
• 1297474-55-5 C₁₉H₁₁ClN₂O₂S 
• 1297474-20-4 C₁₉H₁₃ClN₂O₃S 
• 1297474-35-1 C₁₅H₁₅ClN₂OS 
• 1393641-18-3 ethyl cis-2-diazo-2-(4-(4-chlorophenyl)-1-hydroxycyclohexyl)acetate 
• 1393641-27-4 (S)-4-(4-chlorophenyl)cycloheptan-1-one 
• 1402080-52-7 5-(4-chlorophenyl)oxepan-2-one 
• 1203609-11-3 cis/trans-(4-(4-chlorophenyl)cyclohexyl)naphthalen-1,4-dione 

Relevant articles and documents

Desymmetrizing Isomerization of Alkene via Thiazolinyl Iminoquinoline Cobalt Catalysis

We report a cobalt-catalyzed desymmetrizing isomerization of exo-cyclic alkenes to generate chiral 1-methylcyclohexene derivatives with good yields and enantioselectivities. A novel chiral thiazolinyl iminoquinoline ligand and its cobalt complex were desi

The Silicon-Hydrogen Exchange Reaction: A Catalytic σ-Bond Metathesis Approach to the Enantioselective Synthesis of Enol Silanes

The use of chiral enol silanes in fundamental transformations such as Mukaiyama aldol, Michael, and Mannich reactions as well as Saegusa-Ito dehydrogenations has enabled the chemical synthesis of enantiopure natural products and valuable pharmaceuticals. However, accessing these intermediates in high enantiopurity has generally required the use of either stoichiometric chiral precursors or stoichiometric chiral reagents. We now describe a catalytic approach in which strongly acidic and confined imidodiphosphorimidates (IDPi) catalyze highly enantioselective interconversions of ketones and enol silanes. These "silicon-hydrogen exchange reactions"enable access to enantiopure enol silanes via tautomerizing σ-bond metatheses, either in a deprotosilylative desymmetrization of ketones with allyl silanes as the silicon source or in a protodesilylative kinetic resolution of racemic enol silanes with a carboxylic acid as the silyl acceptor.

Enantioselective Synthesis of Chiral Oxime Ethers: Desymmetrization and Dynamic Kinetic Resolution of Substituted Cyclohexanones

Axially chiral cyclohexylidene oxime ethers exhibit unique chirality because of the restricted rotation of C=N. The first catalytic enantioselective synthesis of novel axially chiral cyclohexylidene oximes has been developed by catalytic desymmetrization of 4-substituted cyclohexanones with O-arylhydroxylamines and is catalyzed by a chiral BINOL-derived strontium phosphate with excellent yields and good enantioselectivities. In addition, chiral BINOL-derived phosphoric acid catalyzed dynamic kinetic resolution of α-substituted cyclohexanones has been performed and yields versatile intermediates in high yields and enantioselectivities.