144730-62-1Relevant articles and documents
Facile two-step synthesis of 3-substituted indazoles using diazo(trimethylsilyl)methylmagnesium bromide
Hari, Yoshiyuki,Sone, Ryosuke,Aoyama, Toyohiko
experimental part, p. 2804 - 2808 (2009/09/07)
Diazo(trimethylsilyl)methylmagnesium bromide readily reacted with various ketones and aldehydes to give the corresponding 2-diazo-(2-trimethylsilyl) ethanols. These were efficiently converted to indazoles bearing hydroxymethyl units at the 3-position by intermolecular [3 + 2] cycloaddition with benzynes. The Royal Society of Chemistry 2009.
A novel synthesis of 3-substituted indazole derivatives
Welch,Hanau,Whalen
, p. 937 - 939 (2007/10/02)
The dianion prepared from 3-bromo-1H-indazole and alkyllithium bases reacts with a variety of electrophiles to give the corresponding 3-monosubstituted 1H-indazole derivatives in moderate yields. This procedure is more general and shorter than earlier methods.