1447952-30-8

Basic information

• Product Name: C₂₅H₂₂O₄
• CAS NO: 1447952-30-8
• Molecular Weight: 386.447
• Mol File: 1447952-30-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₂O₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₂O₄(1447952-30-8)
• EPA Substance Registry System: C₂₅H₂₂O₄(1447952-30-8)

Safety Data

• Hazardous Substances Data: 1447952-30-8(Hazardous Substances Data)

Upstream product

• 620-18-8 3-hydroxystyrene 
• 106824-46-8 4,5-dimethoxy-2-(2-phenylethynyl)benzaldehyde 

Relevant articles and documents

Asymmetric cascade annulation based on enantioselective oxa-diels-alder cycloaddition of in situ generated isochromenyliums by cooperative binary catalysis of Pd(OAc)2 and (S)-trip

An asymmetric cascade annulation between 2-hydroxystyrenes and 2-alkynylbenaldehyes or 1-(2-alkynylphenyl)ketones has been established with good to excellent enantioselectivities (up to >99.5% ee), on the basis of an enantioselective oxa-Diels-Alder cycloaddition of in situ generated metallo-isochromenylium intermediates, by cooperative binary catalysis of Pd(OAc)2 and (S)-Trip. The developed methodology is workable for a broad spectrum of substrates and shows great efficiency in establishing dense multiple chiral centers including quaternary carbons of variable bridged ring systems. The mechanism study suggests that (S)-Trip plays multiple roles in assembling the reactants and controlling the stereoselectivity.