144831-77-6

Basic information

• Product Name: L-Phenylalanine, 3-cyano-N-(2-naphthalenylsulfonyl)-
• CAS NO: 144831-77-6
• Molecular Formula: C20H16N2O4S
• Molecular Weight: 380.424
• Mol File: 144831-77-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: L-Phenylalanine, 3-cyano-N-(2-naphthalenylsulfonyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: L-Phenylalanine, 3-cyano-N-(2-naphthalenylsulfonyl)-(144831-77-6)
• EPA Substance Registry System: L-Phenylalanine, 3-cyano-N-(2-naphthalenylsulfonyl)-(144831-77-6)

Safety Data

• Hazardous Substances Data: 144831-77-6(Hazardous Substances Data)

Upstream product

• 93-11-8 2-Naphthalenesulfonyl chloride 
• 57213-48-6 3-cyano-(D,L)-phenylalanine 
• 194085-41-1 methyl (S)-3-(3-cyanophenyl)-2-(naphthalene-2-sulfonamido)propanoate 

Downstream Products

• 161357-85-3 N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl chloride 
• 1027546-78-6 Naphthalene-2-sulfonic acid [(S)-1-(3-cyano-benzyl)-2-(4-formyl-piperazin-1-yl)-2-oxo-ethyl]-amide 
• 161357-44-4 N^α-(2-naphthylsulfonyl)-3-cyano-L-phenylalanyl-4-(2-hydroxyethyl)piperazide 
• 161357-40-0 Naphthalene-2-sulfonic acid [(S)-2-(4-acetyl-piperazin-1-yl)-1-(3-cyano-benzyl)-2-oxo-ethyl]-amide 
• 161357-47-7 3-[(S)-3-(4-Methanesulfonyl-piperazin-1-yl)-2-(naphthalene-2-sulfonylamino)-3-oxo-propyl]-thiobenzamide 
• 797040-08-5 2-Nas-Phe(3-AcOxam)-OH 

Relevant articles and documents

INHIBITORS OF GROWTH FACTOR ACTIVATION ENZYMES

The present invention generally relates to compounds that are useful for inhibiting one or more of hepatocyte growth factor activator, matriptase, hepsin, Factor Xa, or thrombin. The present invention also relates to various methods of using the inhibitor compounds including treating a malignancy, a pre-malignant condition, or cancer by administering an effective amount of the inhibitor to a subject in need thereof.

N-SULPHONYLATED AMINO ACID DERIVATIVES, METHOD FOR THE PRODUCTION AND USE THEREOF

The invention relates to N-sulphonylated amino acid derivatives wherein an aryl radical is bound to an amino acid via the sulphonyl groups in the N-terminal and a radical is bound in the C-terminal via the carbonyl group. Said radical contains at least one imino group and at least one other basic group representing an optionally modified amino-, amidino- or guanidino group. The invention also relates to a method for the production of said compounds and to the use thereof, especially as inhibitors of matriptase.

META-SUBSTITUTED PHENYLALANINE DERIVATIVES

D,L-, L-and D-phenyl alanine derivatives of formula (I) defined in claim 1 in which R 1 is an amidino-, guanidino-, oxamidino-, aminomethyl-or amino group have been discovered which effectively prevent blood coagulation or thrombosis. The antithrombotically active compounds have low toxicity and may be administered by mouth, subcutaneously or intravenously.