144870-19-9

Basic information

• Product Name: diethyl (2S,3S)-3-(4-bromophenyl)-1-(tert-butoxycarbonyl)-5-oxo-2-pyrrolidinylphosphonate
• CAS NO: 144870-19-9
• Molecular Weight: 476.304
• Mol File: 144870-19-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: diethyl (2S,3S)-3-(4-bromophenyl)-1-(tert-butoxycarbonyl)-5-oxo-2-pyrrolidinylphosphonate(CAS DataBase Reference)
• NIST Chemistry Reference: diethyl (2S,3S)-3-(4-bromophenyl)-1-(tert-butoxycarbonyl)-5-oxo-2-pyrrolidinylphosphonate(144870-19-9)
• EPA Substance Registry System: diethyl (2S,3S)-3-(4-bromophenyl)-1-(tert-butoxycarbonyl)-5-oxo-2-pyrrolidinylphosphonate(144870-19-9)

Safety Data

• Hazardous Substances Data: 144870-19-9(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 3650-78-0 methyl (E)-4-bromocinnamate 
• 104549-54-4 diethyl (aminomethyl)phosphonate (+)-camphor imine 

Relevant articles and documents

Asymmetric Syntheses of α-Aminophosphonic Acids, V - Synthesis of Enantiomerically Pure Diethyl 2-Pyrrolidinyl- and 5-Oxo-2-pyrrolidinylphosphonates

Enantiomerically pure 3- and 4-substituted phosphonic acid derivatives 5 of pyroglutamic acid were prepared by a Michael addition of the lithiated (+)-camphor derivative 2 to α,β-unsaturated esters and subsequent hydrolysis.The reduction of the lactams 5 with LiBH4/BF3*OEt2 afforded substituted phosphonic acid analogues 7 of proline.Key Words: Phosphoglutamic acids / Phosphoprolines / Michael additions / Lactams