144924-88-9

Basic information

• Product Name: 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside
• Synonyms: 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside;2-AMino-6-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine;6-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-2-amine
• CAS NO: 144924-88-9
• Molecular Formula: C₁₀H₁₁ClFN₅O₃
• Molecular Weight: 303.6774432
• Mol File: 144924-88-9.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(144924-88-9)
• EPA Substance Registry System: 2-AMino-6-chloropurine -9-beta-D-(2'-deoxy-2'-fluoro)-arabinoriboside(144924-88-9)

Safety Data

• Hazardous Substances Data: 144924-88-9(Hazardous Substances Data)

Usage

Properties

Chemical compound
Consists of a purine base, a chloro substituent, and a deoxyfluoroarabinose sugar moiety
Anti-cancer properties
Inhibits DNA synthesis
Induces apoptosis in cancer cells
Potential antiviral activity against herpes simplex and varicella-zoster viruses
Investigated for potential use in autoimmune diseases
Valuable in oncology, virology, and immunology research

Specific content

Purine base
Chloro substituent
Deoxyfluoroarabinose sugar moiety
Used in the treatment of chronic lymphocytic leukemia
Potential use as a therapeutic agent in autoimmune diseases
Studied for antiviral activity against herpes simplex and varicella-zoster viruses
Ability to modulate immune responses

Upstream product

• 118373-61-8 2-amino-6-chloro-9-(3',5'-di-O-benzoyl-2'-deoxy-2'-fluoro-β-D-arabinofuranosyl)-9H-purine 
• 97614-44-3 2-deoxy-2-fluoro-3,5-di-O-benzoyl-α-D-arabinofuranosyl bromide 
• 97614-43-2 1,3,5-tri-O-benzoyl-2-deoxy-2-fluoro-α-D-arabinofuranose 
• 10310-21-1 2-Amino-6-chloropurin 
• 850883-62-4 2-deoxy-2-fluoro-α-D-arabinofuranose 1-phosphate 

Downstream Products

• 103884-98-6 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-guanine 

Relevant articles and documents

ANTI-HEPATITIS B VIRUS AGENT

PROBLEM TO BE SOLVED: To provide an anti-hepatitis B virus agent and a prophylactic or therapeutic agent for hepatitis B virus-associated diseases, containing a nucleic acid analog as an active ingredient. SOLUTION: The anti-hepatitis B virus agent and pr

Synthesis and Biological Evaluation of Purine 2′-Fluoro-2′-deoxyriboside ProTides as Anti-influenza Virus Agents

2′-Fluoro-2′-deoxyguanosine has been reported to have potent anti-influenza virus activity invitro and invivo. Herein we describe the synthesis and biological evaluation of 6-modified 2′-fluoro-2′-deoxyguanosine analogues and their corresponding phosphora

Chemistry and anti-HIV activity of 2'-β-fluoro-2',3'-dideoxyguanosine

The 2'-β-fluoro analogue of 2',3'-dideoxyguanosine has been prepared by two synthetic routes. This compound and two analogues have anti-HIV activity in at least two of three host cell systems used (ATH8, CEM, PBL). These compounds, as well as their ddGuo