1450-72-2Relevant articles and documents
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Cullinane,Edwards
, p. 3016,3018 (1957)
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Dinuclear Metal Complexes. Part 2. Synthesis, Characterisation, and Electrochemical Studies of Macrocyclic Dicopper(II) Complexes
Mandal, Sanat Kumar,Nag, Kamalaksha
, p. 2429 - 2434 (1983)
The synthesis, characterisation, and electrochemical studies of dicopper(II) complexes 1>2.nH2O of the macrocycle 7,11;19,23-dimetheno-9,21-dimethyl-tetra-azacycloicosa-5,7,9,12,17,19,21,24-octaene-25,26-diol (H2L1), and of some 6,12,18,24-substituted (Me4; Prn4; Ph4; Ph, Me, Ph, Me) derivatives have been carried out.These compounds undergo sequential one-electron transfers at two different potentials.For all of these compounds, except for 1>2.2H2O, two reversible or almost reversible reduction steps have been observed in acetonitrile medium using a hanging mercury drop electrode.In the case of 1>2.2H2O, the second couple became obscured due to the presence of an adsorption phenomenon or secondary electrode reaction.However, in NN-dimethylformamide (dmf) medium, satisfactory voltammograms have been obtained only with 1>2.2H2O.The mixed-valent complexes are considerably more stable in acetonitrile than is IICuIL1>+ in dmf.The potentials of the first reduction step (E1) remain practically invariant throughout the series and are independent of the extent of magnetic interactions in the dicopper(II) complexes.The potentials of the second reduction step (E2) vary with the alkyl and aryl groups present, and a linear plot has been obtained for E2 vs. the Hammett function ?m.On the basis of previously reported observations and the present study it is inferred that in acetonitrile medium the unpaired electron in the mixed-valent complexes remains localised on one of the copper atoms.
Electrophotocatalytic C?H Heterofunctionalization of Arenes
Huang, He,Lambert, Tristan H.
supporting information, p. 11163 - 11167 (2021/04/19)
The electrophotocatalytic heterofunctionalization of arenes is described. Using 2,3-dichloro-5,6-dicyanoquinone (DDQ) under a mild electrochemical potential with visible-light irradiation, arenes undergo oxidant-free hydroxylation, alkoxylation, and amination with high chemoselectivity. In addition to batch reactions, an electrophotocatalytic recirculating flow process is demonstrated, enabling the conversion of benzene to phenol on a gram scale.
Novel p-functionalized chromen-4-on-3-yl chalcones bearing astonishing boronic acid moiety as MDM2 inhibitor: Synthesis, cytotoxic evaluation and simulation studies
Bhatia, Richa Kaur,Coutinho, Evans C.,Garg, Ruchika,Kancherla, Satyavathi,Kaur, Maninder,Madan, Jitender,Pissurlenkar, Raghuvir R. S.,Singh, Lakhwinder,Yadav, Manmohan
, p. 212 - 228 (2020/03/10)
Background: Novel 4-[3-(6/7/8-Substituted 4-Oxo-4H-chromen-3-yl)acryloyl]phenyl-boronic acid derivatives (5a-h) as well as other 6/7/8-substituted-3-(3-oxo-3-(4-substituted-phenyl)prop-1-enyl)-4H-chromen-4-one derivatives (3a-u) have been designed as p53-MDM2 pathway inhibitors and reported to possess significant cytotoxic properties against several cancer cell lines. Objectives: The current project aims to frame the structure-anticancer activity relationship of chromen-4-on-3-yl chalcones (3a-u/5a-h). In addition, docking studies were performed on these chromeno-chalcones in order to have an insight into their interaction possibilities with MDM2 pro-tein. Methods: Twenty-nine chromen-4-on-3-yl chalcone derivatives (3a-u/5a-h) were prepared by utilizing silica supported-HClO4 (green route with magnificent yield) and tested against four cancer cell lines (HCT116, MCF-7, THP-1, NCIH322). Results: Among the series 3a-u, compound 3b exhibited the highest anticancer activity (with IC50 values ranging from 8.6 to 28.4 μM) overall against tested cancer cell lines. Interestingly, para-Boronic acid derivative (5b) showed selective inhibition against colon cancer cell line, HCT-116 with an IC50 value of 2.35 μM. Besides the emblematic hydrophobic interactions of MDM2 inhibi-tors, derivative 5b was found to exhibit extra hydrogen bonding with GLN59 and GLN72 residues of MDM2 in molecular dynamics (MD) simulation. All the compounds were virtually nontoxic against normal fibroblast cells. Conclusion: Novel compounds were obtained with good anticancer activity especially 6-Chlorochromen-4-one substituted boronic acid derivative 5b. The molecular docking study proposed good activity as a MDM-2 inhibitor suggesting hydrophobic as well as hydrogen bonding interactions with MDM2.