1450642-59-7

Basic information

• Product Name: C₂₃H₂₀F₂N₆
• CAS NO: 1450642-59-7
• Molecular Weight: 418.449
• Mol File: 1450642-59-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₃H₂₀F₂N₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₃H₂₀F₂N₆(1450642-59-7)
• EPA Substance Registry System: C₂₃H₂₀F₂N₆(1450642-59-7)

Safety Data

• Hazardous Substances Data: 1450642-59-7(Hazardous Substances Data)

Upstream product

• 1450642-40-6 3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1-p-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1093676-98-2 3-iodo-5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]pyridine 
• 918522-51-7 5-(1-methyl-1H-pyrazol-4-yl)-1H-pyrrolo[2,3-b]-pyridine 
• 183208-35-7 5-bromo-1H-pyrrolo[2,3-b]pyridine 
• 875639-15-9 5-bromo-3-iodo-1-(4-methylbenzene-1-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 1450643-24-9 C₃₀H₂₆F₂N₆O₂S 
• 1450642-89-3 C₂₆H₂₁BrF₂N₄O₂S 
• 1450642-71-3 C₁₈H₂₃BF₂N₂O₂ 

Relevant articles and documents

Discovery of 7-azaindole based anaplastic lymphoma kinase (ALK) inhibitors: Wild type and mutant (L1196M) active compounds with unique binding mode

We have identified a novel 7-azaindole series of anaplastic lymphoma kinase (ALK) inhibitors. Compounds 7b, 7m and 7n demonstrate excellent potencies in biochemical and cellular assays. X-ray crystal structure of one of the compounds (7k) revealed a unique binding mode with the benzyl group occupying the back pocket, explaining its potency towards ALK and selectivity over tested kinases particularly Aurora-A. This binding mode is in contrast to that of known ALK inhibitors such as Crizotinib and NVP-TAE684 which occupy the ribose binding pocket, close to DFG motif.