145100-50-1 Usage
Description
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE, also known as N-(2-Pyridyl)bis(trifluoromethanesulfonimide), is a chemical compound that serves as a useful triflating reagent. It is synthesized by reacting 2-aminopyridine and triflic anhydride and is characterized by its ability to transfer trifluoromethylsulfonyl (triflyl) groups in chemical reactions.
Uses
Used in Chemical Synthesis:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as an intermediate in the synthesis of aryl triflates and vinyl triflates. Its application in this context is due to its ability to act as a triflating reagent, which is crucial for the formation of these specific chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is used as a reagent for the synthesis of various drug candidates. Its role in this industry is to facilitate the creation of new molecules with potential therapeutic properties, contributing to the development of novel medications.
Used in Research and Development:
2-[N,N-BIS(TRIFLUOROMETHYLSULFONYL)AMINO]PYRIDINE is also utilized in research and development settings, where it is employed to study the properties and reactivity of triflating reagents. This helps scientists understand the underlying mechanisms of various chemical reactions and develop new strategies for synthesizing complex molecules.
Check Digit Verification of cas no
The CAS Registry Mumber 145100-50-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,1,0 and 0 respectively; the second part has 2 digits, 5 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 145100-50:
(8*1)+(7*4)+(6*5)+(5*1)+(4*0)+(3*0)+(2*5)+(1*0)=81
81 % 10 = 1
So 145100-50-1 is a valid CAS Registry Number.
InChI:InChI=1/C7H4F6N2O4S2/c8-6(9,10)20(16,17)15(5-3-1-2-4-14-5)21(18,19)7(11,12)13/h1-4H
145100-50-1Relevant articles and documents
Retinoid-like compounds
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, (2008/06/13)
The present invention relates to a compound of formula I STR1 or a nontoxic pharmaceutically acceptable salt, physiologically hydrolyzable ester or solvate thereof, in whichX is --O--CO--, --NH--CO--, --CS--NH--, --CO--O--, --CO--NH--, --COS--, --SCO--, --SCH 2 --, --CH 2 --CH 2 --, --C C--, --CH 2 --NH--, --COCH 2 --, --NHCS--, --CH 2 S--, --CH 2 O--, --OCH 2 --, --NHCH 2 -- or --CR 5 CR 6 --;R m and R k are independently hydrogen, halogen, C 1-6 alkyl, hydroxy, C 1-6 alkyloxy or nitro;n is zero or one;R 4 is --(CH 2) t --Y, C 1-6 alkyl, or C 3-6 cycloalkyl;R 1 is --CO 2 Z, C 1-6 alkyl, CH 2 OH, --CONHR y, or CHO;R 2 and R 3 are independently hydrogen or C 1-6 alkyl;R a and R b are independently hydrogen or C 1-6 alkyl; but when n is one, R a and R b together can form a radical of the formula STR2 Y is naphthyl or phenyl, both radicals can be optionally substituted with one to three same or different C 1-6 alkyl or halogen;Z is hydrogen or C 1-6 alkyl;R 5, R 6 and R y are independently hydrogen or C 1-6 alkyl; andt is zero to six.
Pyridine-derived triflating reagents: N-(2-pyridyl)-triflimide and n-(5-chloro-2-pyridyl)triflimide
Comins, Daniel L.,Dehghani, Ali,Foti, Christopher J.,Joseph, Sajan P.
, p. 77 - 77 (2017/09/08)
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Pyridine-Derived Triflating Reagents: An Improved Preparation of Vinyl Triflates from Metallo Enolates.
Comins, Daniel L.,Dehghani, Ali
, p. 6299 - 6302 (2007/10/02)
Metallo enolates of ketones are trapped with an N-(2-pyridyl)triflimide at low temperatures to give vinyl triflates.
