145231-45-4

Basic information

• Product Name: CLOBENPROPIT DIHYDROBROMIDE
• Synonyms: ([4-CHLOROPHENYL]METHYL)-3-(1H-IMIDAZOL-4-YL)PROPYL ESTER CARBAMIMIDOTHIOIC ACID DIHYDROBROMIDE;CLOBENPROPIT DIHYDROBROMIDE;VUF 9153;VUF 9153 DIHYDROBROMIDE;N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA;N-(4-CHLOROBENZYL)-S-[3-(4(5)-IMIDAZOLYL)PROPYL]ISOTHIOUREA DIHYDROBROMIDE;VUF 9153, [(4-Chlorophenyl)methyl]-3-(1H-imidazol-4-yl)propyl ester carbamimidothioic acid dihydrobromide;N-(4-Chlorobenzyl)-S-[3-(4(5)-imidazoyl)propyl]isothiourea dihydrobromide
• CAS NO: 145231-45-4
• Molecular Formula: C14H19Br2ClN4S
• Molecular Weight: 470.65
• EINECS: 604-604-1
• Product Categories: Histamine receptor
• Mol File: 145231-45-4.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 551.3°Cat760mmHg
• Flash Point: 287.2°C
• Appearance: white/solid
• Density: 1.31g/cm³
• Vapor Pressure: 3.35E-12mmHg at 25°C
• Refractive Index: 1.645
• Storage Temp.: 2-8°C
• Solubility: H2O: >20 mg/mL
• PKA: 14.55±0.10(Predicted)
• CAS DataBase Reference: CLOBENPROPIT DIHYDROBROMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: CLOBENPROPIT DIHYDROBROMIDE(145231-45-4)
• EPA Substance Registry System: CLOBENPROPIT DIHYDROBROMIDE(145231-45-4)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 145231-45-4(Hazardous Substances Data)

Usage

Description

CLOBENPROPIT DIHYDROBROMIDE is an imidothiocarbamic ester that consists of isothiourea bearing S-3-(imidazol-4-yl)propyl and N-4-chlorobenzyl substituents. It is an extremely potent histamine H3 antagonist/inverse agonist.

Uses

Used in Pharmaceutical Industry:
CLOBENPROPIT DIHYDROBROMIDE is used as a histamine H3 antagonist/inverse agonist for its potent ability to modulate histamine H3 receptors, which can have various therapeutic applications in the treatment of different conditions.
Used in Research Applications:
CLOBENPROPIT DIHYDROBROMIDE is used as a research tool for studying the role of histamine H3 receptors in various physiological processes and their potential as targets for drug development. Its high potency makes it a valuable compound for investigating the mechanisms of histamine H3 receptor signaling and its implications in various diseases.
Used in Drug Development:
CLOBENPROPIT DIHYDROBROMIDE is used as a lead compound in the development of new drugs targeting histamine H3 receptors. Its potent antagonist/inverse agonist activity can be leveraged to create more selective and effective medications for treating conditions related to histamine H3 receptor dysregulation.

Biological Activity

An extremely potent histamine H 3 antagonist/inverse agonist (pA 2 =9.93). Also displays partial agonist activity at H 4 receptors; induces eosinophil shape change with an EC 50 of 3 nM. Also available as part of the Histamine H 3 Receptor Tocriset? .

Biochem/physiol Actions

Selective H3 histamine receptor antagonist that crosses the blood-brain barrier.

InChI:InChI=1/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)