1452807-21-4

Basic information

• Product Name: C₁₈H₂₀N₄O
• Synonyms: C₁₈H₂₀N₄O
• CAS NO: 1452807-21-4
• Molecular Weight: 308.383
• Mol File: 1452807-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₈H₂₀N₄O(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₈H₂₀N₄O(1452807-21-4)
• EPA Substance Registry System: C₁₈H₂₀N₄O(1452807-21-4)

Safety Data

• Hazardous Substances Data: 1452807-21-4(Hazardous Substances Data)

Upstream product

• 67292-98-2 3-nitro-2-phenylimidazo<1,2-a>pyridine 
• 67625-22-3 2-bromo-3-nitro-imidazo[1,2-a]pyridine 
• 98-80-6 phenylboronic acid 
• 112581-95-0 2-Bromoimidazo[1,2-a]pyridine 
• 504-29-0 2-aminopyridine 
• 3999-05-1 2-chloroimidazo[1,2-a]pyridine 
• 126202-06-0 2-(2-imino-1,2-dihydropyridin-1-yl)acetic acid 
• 3999-29-9 2-phenylimidazo[1,2-a]pyridin-3-amine 
• 111-36-4 n-butyl isocyanide 

Relevant articles and documents

Exploration of versatile reactions on 2-chloro-3-nitroimidazo[1,2-a] pyridine: Expanding structural diversity of C2- and C3-functionalized imidazo[1,2-a]pyridines

Alternative strategies for functionalizing 2-chloro-3-nitroimidazo[1,2-a] pyridine have been developed. Suzuki-Miyaura cross-coupling reaction provided easily the corresponding 2-arylated compounds, and herefrom the nitro group was reduced into amine which afforded amides, anilines, and ureas in the 3-position. The amination of the key compound using a metal-catalyzed reaction was reported. This study highlighted the importance of the nitro group to facilitate the chlorine displacement. Other nucleophilic aromatic substitutions open a route to various products derived from imidazo[1,2-a]pyridine.