1452864-25-3

Basic information

• Product Name: C₂₅H₂₇N₅O₂
• CAS NO: 1452864-25-3
• Molecular Weight: 429.522
• Mol File: 1452864-25-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₂₇N₅O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₂₇N₅O₂(1452864-25-3)
• EPA Substance Registry System: C₂₅H₂₇N₅O₂(1452864-25-3)

Safety Data

• Hazardous Substances Data: 1452864-25-3(Hazardous Substances Data)

Upstream product

• 16849-91-5 (R)-(+)-N-α-methylbenzylurea 
• 1452864-20-8 C₁₇H₁₈N₄O₃ 
• 1452864-18-4 C₁₂H₈ClN₃O₂ 
• 1452864-17-3 methyl 4-oxo-4,5-dihydroimidazo[1,2-a]quinoxaline-8-carboxylate 
• 1452864-16-2 C₁₄H₁₃N₃O₆ 
• 185629-31-6 methyl 3-fluoro-4-nitrobenzoate 

Relevant articles and documents

Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a] quinoxalin-4-amine derived JNK1 inhibitors

As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 μM rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50 = 160 nM) which was co-crystallized with JNK1 to identify key molecular interactions. Kinase profiling against 125+ kinases revealed AX13587 was an inhibitor of JNK, MAST3, and MAST4 whereas its methylene homolog AX14373 (native JNK1 IC50 = 47 nM) was a highly specific JNK inhibitor.