145473-87-6

Basic information

• Product Name: Acetamide, N-(4-methylphenyl)-N-phenyl-
• CAS NO: 145473-87-6
• Molecular Formula: C15H15NO
• Molecular Weight: 225.29
• Mol File: 145473-87-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: Acetamide, N-(4-methylphenyl)-N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide, N-(4-methylphenyl)-N-phenyl-(145473-87-6)
• EPA Substance Registry System: Acetamide, N-(4-methylphenyl)-N-phenyl-(145473-87-6)

Safety Data

• Hazardous Substances Data: 145473-87-6(Hazardous Substances Data)

Upstream product

• 620-84-8 4-methyldiphenylamine 
• 75-36-5 acetyl chloride 
• 108-86-1 bromobenzene 
• 103-89-9 4-Methylacetanilide 
• 5720-05-8 4-methylphenylboronic acid 
• 103-84-4 Acetanilid 
• 66003-76-7 Diphenyliodonium triflate 
• 579-11-3 N-chloroacetanilide 
• 2417-95-0 p-tolyllithium 
• 62-53-3 aniline 
• 106-49-0 p-toluidine 
• 591-50-4 iodobenzene 
• 624-31-7 4-tolyl iodide 
• 76154-06-8 N-phenyl-(1-(4-methylphenyl)ethylidene)amine 

Downstream Products

• 150253-60-4 N-<4-(2-bromomethyl)phenyl>-N-phenylacetamide 
• 150253-65-9 N-{4-[(Methyl-naphthalen-1-ylmethyl-amino)-methyl]-phenyl}-N-phenyl-acetamide 

Relevant articles and documents

Method for preparing N,N-diarylamide derivatives

The invention provides a method for preparing N,N-diarylamide derivatives and belongs to the technical field of chemical synthesis. The method comprises the following steps: taking N-arylamide and phenylboronic acid as raw materials, stirring in an organic solvent under blue light irradiation for 30-44 hours so as to obtain crude N,N-diarylamide, extracting and washing the crude product, and performing column chromatography isolation, thereby obtaining the high-purity N,N-diarylamide derivative. The method disclosed by the invention is simple and readily available in raw materials, mild in reaction condition and simple in operation, and the N,N-diarylamide derivatives with structural diversity can be easily obtained by changing the structures of the raw materials and have excellent application and market value.

Copper/N,N-dimethylglycine catalyzed Goldberg reactions between aryl bromides and amides, aryl iodides and secondary acyclic amides

An efficient and general copper-catalyzed Goldberg reaction at 90-110 °C between aryl bromides and amides providing the desired products in good to excellent yields has been developed using N,N-dimethylglycine as the ligand. The reaction is tolerant toward a wide range of amides and a variety of functional group substituted aryl bromides. In addition, hindered, unreactive aromatic and aliphatic secondary acyclic amides, known to be poor nucleophiles, are efficiently coupled with aryl iodides through this simple and cheap copper/N,N-dimethylglycine catalytic system.

Aryl halide tolerated electrophilic amination of arylboronic acids with N-chloroamides catalyzed by CuCl at room temperature

(Chemical Equation Presented) N-Cl is no competition: Aryl halides were tolerated in an efficient ligandless CuCl-catalyzed electrophilic amination reaction of arylboronic acids with N-chloroamides (see scheme; Ac=acetoxy). This coupling proceeded smoothly at ambient temperature, and products were obtained with good to excellent yields.