14551-15-6Relevant articles and documents
Compounds and methods for the enrichment of mutated nucleic acid from a mixture
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Paragraph 0048-0049, (2016/06/01)
The detection of the presence of rare somatic mutations from a biological sample is often challenging due to the simultaneous presence of a vast excess of wild-type DNA. The present invention describes novel compounds and methods that would allow the enrichment of mutant DNA by depleting amplifiable wild-type DNA.