1456-21-9Relevant articles and documents
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Holmberg
, p. 2,3 (1944)
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Synthesis of 1,3,4-thiadiazoles from aldehyde hydrazones
Okuma, Kentaro,Nagakura, Kazuko,Nakajima, Yasutaka,Kubo, Kento,Shioji, Kosei
, p. 1929 - 1931 (2004)
Reaction of p-tolualdehyde hydrazone with disulfur dichloride in the presence of DBU gave 2,5-di (p-tolyl)-1,3,4-thiadiazole (1a) in 54% yield. Phenyldiazomethane also reacted with disulfur dichloride to afford 2,5-diphenyl-1,3,4-thiadiazole (1b) in 80% y
Synthesis of substituted 1,3,4-thiadiazoles using Lawesson's reagent
Gierczyk,Zalas
, p. 213 - 222 (2005)
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TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles
Zhang, Lin,Yu, Yu,Tang, Qiang,Yuan, Jianyong,Ran, Dongzhi,Tian, Binghua,Pan, Tao,Gan, Zongjie
, p. 423 - 431 (2019/12/27)
An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.
Preparation method of 1, 3, 4-thiadiazole compound and compound prepared by preparation method
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Paragraph 0019-0020; 0061-0062, (2020/12/10)
The invention belongs to the field of medicinal chemistry. Specifically, the invention discloses a preparation method of a 1, 3, 4-thiadiazole compound and the compound prepared by using the preparation method. According to the method, the 1, 3, 4-thiadia