145783-14-8 Usage
Description
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE is an organic compound with the molecular formula C8H7Cl2N3O2S. It is characterized by the presence of two chlorine atoms at the 4 and 6 positions, a nitro group at the 5 position, and a propylthio group at the 2 position. 4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE serves as a key intermediate in the synthesis of various biologically active molecules.
Uses
Used in Pharmaceutical Industry:
4,6-DICHLORO-5-NITRO-2-PROPYLTHIOPYRIMIDINE is used as a reactant in the synthesis of carba-nucleosides, which are potent antagonists of the ADP purinergic receptor P2Y12 on human platelets. These antagonists play a crucial role in the prevention of blood clot formation, making them valuable in the treatment and management of conditions such as atherosclerosis, acute coronary syndrome, and stroke.
The compound's unique structural features allow it to be a versatile building block in the development of new therapeutic agents targeting various diseases. Its application in the pharmaceutical industry is primarily focused on the synthesis of novel compounds with potential therapeutic benefits.
Check Digit Verification of cas no
The CAS Registry Mumber 145783-14-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,5,7,8 and 3 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 145783-14:
(8*1)+(7*4)+(6*5)+(5*7)+(4*8)+(3*3)+(2*1)+(1*4)=148
148 % 10 = 8
So 145783-14-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H7Cl2N3O2S/c1-2-3-15-7-10-5(8)4(12(13)14)6(9)11-7/h2-3H2,1H3
145783-14-8Relevant articles and documents
Pyrimido triazole compound and medical application thereof (by machine translation)
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Paragraph 0043; 0072-0075, (2020/05/30)
The present invention relates to a compound of general (I) or a hydrate thereof or a pharmaceutically acceptable salt, thereof, a hydrate thereof or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same or a pharmaceutically acceptable salt thereof, and use, of the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament . The medicament is for anti-platelet aggregation and treatment of related diseases such as antithrombotic . (by machine translation)
METHOD FOR PREPARATION OF CHLORINATED S-PROPYLTHIOBARBITURIC ACID
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Page/Page column 10, (2019/02/06)
The invention discloses a method for preparation of 4,6-dichloro-5-nitro-2- (propylthio)pyrimidine by conversion of 5-nitro-2-propylthiopyrimidine-4,6-diol with phosgene in the presence of DMF.
For the improvement of the [...] intermediates preparation method
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Paragraph 0250-0252, (2018/02/04)
The invention relates to an improved preparation method for the intermediate 4, 6-dihalogen-2-(propythio)pyrimidine-5-amine used for preparing the anticoagulation drug ticagrelor, and application of the intermediate in preparation of ticagrelor. By use of a phase transfer reagent, the method reduces the halogenating reagent consumption and emission and treatment of toxic substances. Also, the obtained product has high yield and good purity. Thus, the method is a greener and more economical preparation method more suitable for industrial application.