14579-97-6

Basic information

• Product Name: 2-(p-Bromophenyl)acetyl hydrazide
• Synonyms: 2-(p-Bromophenyl)acetyl hydrazide;N'-(4-Bromophenyl)acetohydrazide;N-Acetyl-N'-(4-bromophenyl)hydrazine, Acetic acid N'-(4-bromophenyl)hydrazide
• CAS NO: 14579-97-6
• Molecular Formula: C₈H₉BrN₂O
• Molecular Weight: 229.07386
• Mol File: 14579-97-6.mol
• Article Data: 7

Chemical Properties

• Melting Point: 161 °C
• Boiling Point: 426.1°Cat760mmHg
• Flash Point: 211.5°C
• Appearance: /
• Density: 1.547g/cm³
• Vapor Pressure: 1.82E-07mmHg at 25°C
• Refractive Index: 1.6
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.62±0.23(Predicted)
• CAS DataBase Reference: 2-(p-Bromophenyl)acetyl hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(p-Bromophenyl)acetyl hydrazide(14579-97-6)
• EPA Substance Registry System: 2-(p-Bromophenyl)acetyl hydrazide(14579-97-6)

Safety Data

• Hazardous Substances Data: 14579-97-6(Hazardous Substances Data)

Usage

General Description

2-(p-Bromophenyl)acetyl hydrazide is a chemical compound with the molecular formula C8H9BrN2O and a molar mass of 216.07 g/mol. It is also known as 2-(4-bromophenyl)acetohydrazide and is used in organic synthesis and pharmaceutical research. 2-(p-Bromophenyl)acetyl hydrazide is a hydrazide derivative and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. It is a white to off-white crystalline solid that is soluble in organic solvents such as acetone and dichloromethane. 2-(p-Bromophenyl)acetyl hydrazide is also known for its ability to inhibit the enzyme acetylcholinesterase, making it a potential candidate for the development of drugs to treat Alzheimer's disease.

InChI:InChI=1/C8H9BrN2O/c9-7-3-1-6(2-4-7)5-8(12)11-10/h1-4H,5,10H2,(H,11,12)

Upstream product

• 507-09-5 thioacetic acid 
• 108-24-7 acetic anhydride 
• 589-21-9 (4-bromophenyl)hydrazine 
• 113157-91-8 (1R)-bornan-2-one-(4-bromo-phenylhydrazone); (d-camphor)-(4-bromo-phenylhydrazone) 
• 64-19-7 acetic acid 
• 463-51-4 Ketene 
• 60-29-7 diethyl ether 
• 114-83-0 1-acetyl-2-phenylhydrazine 
• 95679-79-1 (4-Bromo-phenyl)-(2-methyl-benzo[1,3]dioxol-2-yl)-diazene 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 7732-18-5 water 
• 95679-74-6 2-{1-[(4-Bromo-phenyl)-hydrazono]-ethyl}-phenol 
• 103-02-6 acetone phenylhydrazone 

Downstream Products

• 857815-62-4 N'-acetyl-N-(4-bromo-phenyl)-N-chloroacetyl-hydrazine 
• 74305-91-2 acetyl chloride 4-bromophenylhydrazone 
• 90560-93-3 N'-(4-bromophenyl)-N'-methylacetohydrazide 
• 1259224-11-7 5-bromo-2,3-diphenyl-1H-indole 
• 13041-70-8 (E)-4-bromostilbene 

Relevant articles and documents

Palladium/copper-catalyzed arylation of alkenes with N′-acyl arylhydrazines

A novel ligand-free palladium/copper-catalyzed Heck-type coupling reaction of alkenes and N′-acyl arylhydrazines has been developed by using air as the terminal oxidant. This protocol features wide functional group tolerance and produces highly chemoselective and regioselective products with good to excellent yields.

Synthesis of 2,3-dihydro-1H-indazoles by Rh(iii)-catalyzed C-H cleavage of arylhydrazines

A rhodium-catalyzed efficient method for the synthesis of 2,3-dihydro-1H-indazoles is described. The reaction of arylhydrazines with olefins results in the corresponding 2,3-dihydro 1H-indazoles with exclusive regioselectivity via C-H bond activation. The utility of the methodology is illustrated by a rapid synthesis of 1H-indazoles under mild reaction conditions in half an hour. This journal is the Partner Organisations 2014.

Formation of enehydrazine intermediates through coupling of phenylhydrazines with vinyl halides: Entry into the Fischer indole synthesis

Cut to the chase: Direct formation of an enehydrazine, an intermediate in the classic Fischer indole synthesis, solves the regioselectivity problem associated with indolization. This approach not only achieves selective synthesis of indoles through proper selection of the vinyl halide, but also leads to quick construction of desoxyeseroline and esermethole, as well as the key structural motif in the Akuammiline alkaloid vincorine. Copyright