145822-78-2Relevant articles and documents
Reductive Halogenation Reactions: Selective Synthesis of Unsymmetrical α-Haloketones
Lao, Zhiqi,Zhang, Huimiao,Toy, Patrick H.
supporting information, p. 8149 - 8152 (2019/10/21)
A method for the selective synthesis of unsymmetrical α-haloketones has been developed. The key transformation is a triphenylphosphine oxide catalyzed reductive halogenation of an α,β-unsaturated ketone in which trichlorosilane is the reducing reagent and an N-halosuccinimide is the electrophilic halogen source. This method allows for a halogen atom to be installed selectively at either of two very similarly substituted sites adjacent to a ketone group.
2, 3'-disubstituted-2-(2'-carboxycyclopropyl)glycines as potent and selective antagonists of metabotropic glutamate receptors
Collado, Ivan,Ezquerra, Jesus,Mazon, Angel,Pedregal, Concepcion,Yruretagoyena, Belen,Kingston, Anne E.,Tomlinson, Rosemary,Wright, Rebecca A.,Johnson, Bryan G.,Schoepp, Darryle D.
, p. 2849 - 2854 (2007/10/03)
2-(9-Xanthylmethyl)-2-(2'-carboxycyclopropyl) glycine 6e is a novel metabotropic glutamate receptor antagonist. A series of alpha, C-3' disubstituted (carboxycyclopropyl)glycines 6f-n were prepared. Antagonist activity was observed for all these compounds at group 2 and group 3 mGluRs. Although they were slightly less active on group 2 mGluRs than non C-3, substituted 6e, the compounds 6f-n were more selective with lesser or no activity on group 1 mGluR subtypes (IC50 values greater than 100μm).
Synthesis of α,β-Unsaturated Ketones Using Allylidenetriphenylphosphorane as a Three-carbon Unit
Hatanaka, Minoru,Imashiro, Ritsuo,Ueda, Ikuo
, p. 2253 - 2256 (2007/10/02)
3-Alkoxycarbonyl-2-ethoxy-2-propenylidenetriphenylphosphorane reacts in turn with alkyl halides and aldehydes in the presence of base via a one-pot procedure to give moderate to good yields of conjugated enol ethers.Hydrolysis of the conjugated enol ethers and subsequent decarboxylation provide a novel route to α,β-unsaturated ketones.
