145967-50-6Relevant articles and documents
Design, synthesis, and biological activity of novel triazole amino acids used to probe binding interactions between ligand and neutral amino acid transport protein SN1
Gajewski, Mariusz,Seaver, Ben,Esslinger, C. Sean
, p. 4163 - 4166 (2007)
Novel triazole amino acids were synthesized as probes to investigate ligand-protein binding interactions of the neutral amino acid transporter SN1. The bonding hypothesis to be tested was that the side chains of endogenous substrates are acting as H-bond acceptors. Although limited inhibition of 3H-l-glutamine uptake by SN1 expressing oocytes was observed, the synthetic compounds show a trend that suggests a hydrogen bond interaction just outside the endogenous ligand binding pocket.
Stable triazolylphosphonate analogues of phosphohistidine
Mukai, Shin,Flematti, Gavin R.,Byrne, Lindsay T.,Besant, Paul G.,Attwood, Paul V.,Piggott, Matthew J.
experimental part, p. 857 - 874 (2012/10/07)
Histidine-phosphorylated proteins and the corresponding kinases are important components of bacterial and eukaryotic cell-signalling pathways, and are therefore potential drug targets. The study of these biomolecules has been hampered by the lability of the phosphoramidate functional group in the phosphohistidines and the lack of generic antibodies. Herein, the design and concise synthesis of stable triazolylphosphonate analogues of N1-and N3-phosphohistidine, and derivatives suitable for bioconjugation, are described. Springer-Verlag 2011.
PHOSPHOHISTIDINE ANALOGS
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Page/Page column 62-63, (2012/04/10)
The present invention relates to the phosphohistidine analogs of the present invention which of the formula (I) and the hapten containing the residue of same. It also relates to the hapten conjugated to a carrier molecule and the isolated antibodies raise
