146164-70-7Relevant articles and documents
A selenium-containing ruthenium complex as a cancer radiosensitizer, rational design and the important role of ROS-mediated signalling
Deng, Zhiqin,Yu, Lianling,Cao, Wenqiang,Zheng, Wenjie,Chen, Tianfeng
, p. 2637 - 2640 (2015)
A novel selenium-containing ruthenium complex Ru(phtpy)(phenSe)Cl(ClO4) (phtpy = 4-phenyl-2,2′:6′,2′′-terpyridine, phenSe = 2-selenicimidazole[4,5-f]1,10-phenanthroline) has been synthesized and found be able to enhance radiation-induced DNA damage through superoxide overproduction, which leads to G2/M arrest and apoptosis in cancer cells by activating ROS-mediated pathways. This journal is
Catalytic Water-Oxidation Activity of a Weakly Coupled Binuclear Ruthenium Polypyridyl Complex
Matias, Tiago A.,Mangoni, Ana P.,Toma, Sergio H.,Rein, Francisca N.,Rocha, Reginaldo C.,Toma, Henrique E.,Araki, Koiti
, p. 5547 - 5556 (2016)
The catalytic oxidation of water by the binuclear complex [Ru2(H2O)2(bpy)2(tpy2ph)](PF6)4[bpy = 2,2′-bipyridine; tpy2ph = 1,3-bis(4′-2,2′:6′,2′′-terpyridin-4-yl)benzene] was investigated comparatively to its mononuclear counterpart [Ru(H2O)(bpy)(phtpy)](PF6)2(phtpy = 4′-phenyl-2,2′:6′,2′′-terpyridine). These catalysts were prepared from the synthesis of their precursor chloride complexes, which were also extensively characterized in this work. The H2O–RuIIcomplexes were found to undergo proton-coupled electron-transfer processes to generate the redox species HO–RuIII, O=RuIV, and O=RuV. The catalytically active species, [RuV2(O)2(bpy)2(tpy2ph)]6+and [RuV(O)(bpy)(phtpy)]3+, were generated electrochemically and by using cerium(IV) ammonium nitrate. In the presence of CeIV, the catalytic rates for O2production by the binuclear and mononuclear species were 1.9 × 10–3and 9.5 × 10–5s–1, respectively. This superior catalytic performance of the binuclear complex suggests that, despite weak electronic coupling between the Ru centers, the second site could play an important mechanistic role in the formation of the activated species [(bpy)(OO)RuIV(tpy2ph)RuIII(OH)(bpy)]4+.
Labile ruthenium(II) complexes with extended phenyl-substituted terpyridyl ligands: Synthesis, aquation and anticancer evaluation
Huang, Huaiyi,Zhang, Pingyu,Chen, Yu,Ji, Liangnian,Chao, Hui
, p. 15602 - 15610 (2015)
Ruthenium complexes have been considered as promising substitutes for cisplatin in cancer chemotherapy. However, novel ruthenium-based therapies are faced with some limitations, such as unimpressive cytotoxicity toward solid tumors. Herein, we designed and synthesized phenyl-substituted terpyridyl ruthenium(ii) complexes ([Ru(tpy)(bpy)Cl]+ (Ru1), [Ru(phtpy)(bpy)Cl]+ (Ru2) and [Ru(biphtpy)(bpy)Cl]+ (Ru3)) which exhibited distinctly different anticancer activity. Ru1-Ru3 all underwent moderate aquation in buffer solution and this process was significantly inhibited by high chloride concentration. Cancer cells were found to readily uptake the relatively hydrophobic Ru3, as quantified using inductively coupled plasma mass spectrometry (ICP-MS). Ru1 was found to be non-cytotoxic (IC50 > 100 μM) while Ru3 exhibited very promising cytotoxicity on both two-dimensional (2D) cancer cell monolayers and 3D MCTSs. An antiproliferative assay revealed that Ru3 significantly inhibited cellular DNA replication which ultimately induced apoptosis of cancer cells.
Synthesis, characterization, and biological evaluation of new RU(ii) polypyridyl photosensitizers for photodynamic therapy
Frei, Angelo,Rubbiani, Riccardo,Tubafard, Solmaz,Blacque, Olivier,Anstaett, Philipp,Felgentr?ger, Ariane,Maisch, Tim,Spiccia, Leone,Gasser, Gilles
, p. 7280 - 7292 (2014)
Two Ru(II) polypyridyl complexes, Ru(DIP)2(bdt) (1) and [Ru(dqpCO2Me)(ptpy)]2+(2) (DIP = 4,7-diphenyl-1,10-phenanthroline, bdt = 1,2-benzenedithiolate, dqpCO2Me = 4-methylcarboxy-2,6-di(quinolin-8-yl)pyridine),
Remote control of electronic coupling-modification of excited-state electron-transfer rates in Ru(tpy)2-based donor-acceptor systems by remote ligand design
Luo, Yusen,Tran, Jens H.,W?chtler, Maria,Schulz, Martin,Barthelmes, Kevin,Winter, Andreas,Rau, Sven,Schubert, Ulrich S.,Dietzek, Benjamin
supporting information, p. 2273 - 2276 (2019/02/27)
A comprehensive understanding of how the molecular structure influences the electronic coupling is crucial in optimizing (supra) molecular assemblies for photoinduced electron transfer. Here, we report that the electronic coupling underlying electron transfer from a phenothiazine donor to a photoexcited Ru(tpy)2 acceptor is modulated by substitution of the second (remote) tpy-ligand.
