1463-64-5Relevant articles and documents
NEW TRIAZINOINDOLE COMPOUNDS
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Page/Page column 60-61, (2021/11/06)
The invention relates to novel compounds for use as inhibitors of NLRP3 inflammasone production, wherein such compounds are as defined by compounds of formula (I) and wherein the integers R1, R2, R3a and R3b are defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of a disease or disorder that is associated with NLRP3 inflammasome activity.
Synthesis of Substituted 2-(5'-Oxo/thioxo-1',3',4'-oxodiazol-2'-yl)indoles and 2-(5'-Oxo/thioxo-1,3,4'-oxodiazol-2'-ylamino)indoles
Hiremath, Shivayogi P.,Hiremath, Dakshayani M.,Purohit, Muralidhar G.
, p. 571 - 576 (2007/10/02)
Indole-2-carboxylates (1a-i) and indole-2-carbamates (12d-i) react with hydrazine hydrate in ethanol to give the corresponding hydrazides (2a-i) and semicarbazides (13d-i).These compounds when heated under reflux with CS2 and KOH give 2-(5'-thioxo-1',3',4'-oxadiazol-2'-yl)indoles (5c,g) and 2-(5'-thioxo-1',3',4'-oxadiazol-2'-ylamino)indoles (16f,g,i).Compounds 2a-i and 13d-i undergo condensation with ethyl chloroformate to give the products 3a-g and 14d,g,h, respectively which on heating under reflux with diphenyl ether give the corresponding 2-(5'-oxo-1',3',4'-oxadiazol-2'-yl)indoles (4a-g) and 2-(5'-oxo-1',3',4'-oxadiazol-2'-ylimino)indoles (15d,g,h).Ethyl 2-phenylindole-3-carbamate (18), obtained from 3-aminoindole (17), has been condensed with hydrazine hydrate to give the semicarbazide (19) which on reation with ethyl chloroformate and heating under reflux with diphenyl ether produces 3-(5'-oxo-1',3',4'-oxadiazol-2'-ylamino)indole (21).
