146563-40-8 Usage
Description
4-bromobutyl nitrate is an organic compound that serves as a crucial intermediate in the synthesis of Latanoprostene Bunod (L177335), a medication used to treat interocular pressure.
Uses
Used in Pharmaceutical Industry:
4-bromobutyl nitrate is used as a synthetic intermediate for the production of Latanoprostene Bunod (L177335), which is a derivative of Latanoprost. 4-bromobutyl nitrate is utilized in the treatment of interocular pressure, helping to manage and reduce the pressure within the eye, thus preventing potential vision loss and damage to the optic nerve.
Preparation
4-Bromobutyl nitrate is a thermally unstable oily liquid, which is used to obtain nitrooxyalkyl esters of pharmacologically active carboxylic acids (WO 04/020384, WO 04/020385). 4-Bromobutyl nitrate not dissolved in solvents is added to the solution / suspension of pharmacologically active carboxylic acids such as naproxen, ferulic acid, etc. 4-Bromobutyl nitrate is obtained by nitration with a sulfonitizing mixture of 4-bromo-1-hydroxybutane (Chem. Pharm. Bull., 1993, 41, p. 1040). The reaction is carried out by adding 4-bromo-1-hydroxybutane to the crude sulphonating mixture in the absence of solvents or diluents. The reaction is limited to a laboratory scale since the method is potentially explosive due to a sudden increase in temperature and gas production.https://patents.google.com/patent/RU2388746C2/en
Check Digit Verification of cas no
The CAS Registry Mumber 146563-40-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,6,5,6 and 3 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 146563-40:
(8*1)+(7*4)+(6*6)+(5*5)+(4*6)+(3*3)+(2*4)+(1*0)=138
138 % 10 = 8
So 146563-40-8 is a valid CAS Registry Number.
146563-40-8Relevant articles and documents
[...] curved nitroxide derivative and its preparation method and application (by machine translation)
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Paragraph 0067; 0069, (2019/01/06)
The invention discloses a sand-kouba curved nitroxide derivatives, have the formula I shown in the chemical structure of: Also discloses the sand kouba curved nitrooxyderivatives pharmaceutically acceptable salts or its pharmaceutically acceptable solvates. Also discloses a pharmaceutical composition, comprising a pharmaceutically-acceptable carrier, a pharmaceutically effective amount of the nitroxide derivatives [...] curved and/or its salt or stereoisomers. Also disclosed sand kouba curved nitrooxyderivatives of the preparation method, and [...] curved nitroxide derivatives or a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof in the preparation of a medicament for treating cardiovascular diseases in the application. (by machine translation)
NITROXY DERIVATIVES OF SOFT STEROIDS
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Page/Page column 17, (2013/09/26)
A compound of formula (I) or a pharmaceutically acceptable salt thereof, and an ophthalmic composition comprising a compound of formula (I) or a pharmaceutically acceptable salt thereof. The invention is also directed to the use of the ophthalmic compositions for treating inflammatory conditions of the palpebral or bulbar conjunctiva, cornea and anterior segment of the globe, and to ameliorate inflammation associated with corneal injury.
PROSTAGLANDIN DERIVATIVES
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Page/Page column 59, (2008/06/13)
Nitroderivatives of prostaglandin amides having improved pharmacological activity and enhanced tolerability are described. They can be employed for the treatment of glaucoma and ocular hypertension.