14663-23-1Relevant articles and documents
SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF DANTROLENE AND SODIUM DANTROLENE
Oleinik, A. F.,Andreeva, N. I.,Syubaev, R. D.,Golovina, S. M.,Vozyakova, T. I.
, p. 310 - 312 (2007/10/02)
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TCI America
(D3996) Dantrolene Sodium Salt Hydrate >98.0%(HPLC)(T)
14663-23-1
1g
690.00CNY
TCI America
(D3996) Dantrolene Sodium Salt Hydrate >98.0%(HPLC)(T)
14663-23-1
5g
2,150.00CNY
Sigma
(D9175) Dantrolenesodiumsalt
14663-23-1
D9175-100MG
836.55CNY
Sigma
(D9175) Dantrolenesodiumsalt
14663-23-1
D9175-250MG
1,854.45CNY
Sigma
(D9175) Dantrolenesodiumsalt
14663-23-1
D9175-1G
5,054.40CNY
Version: 1.0
Creation Date: Aug 10, 2017
Revision Date: Aug 10, 2017
Product name | dantrolene sodium (anhydrous) |
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Product number | - |
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Other names | 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt Hydrate |
Identified uses | For industry use only. |
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Uses advised against | no data available |
Emergency phone number | - |
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Service hours | Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours). |
More Details:14663-23-1 SDS
dantrolene
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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With sodium methylate In methanol at 20℃; for 3h; | 100% |
5-(4-nitrophenyl)-2-furaldehyde
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 2 steps 1: 81 percent / H2O; dimethylformamide 2: 100 percent / CH3ONa / methanol / 3 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
dantrolene
Conditions | Yield |
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With acetic acid In N,N-dimethyl-formamide at 20℃; | 98% |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
tert-butyl 4-(2-iodoethyl)piperidine-1-carboxylate
Conditions | Yield |
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In N,N-dimethyl-formamide at 20℃; | 96.4% |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
tert-butyl 4-(iodomethyl)piperidine-1-carboxylate
Conditions | Yield |
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In N,N-dimethyl-formamide at 20℃; | 51.6% |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
di-tert-butyl chloromethyl phosphate
Conditions | Yield |
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With sodium iodide In N,N-dimethyl-formamide at 0 - 20℃; for 64h; Temperature; | 45% |
N-[(1,1-dimethylethoxy)carbonyl]glycine chloromethyl ester
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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In N,N-dimethyl-formamide at 20℃; for 110h; | 27% |
tert-butyl chloromethyl butanedioate
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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In N,N-dimethyl-formamide at 20℃; for 20h; | 20% |
1-benzyl-4-(2-hydroxyethyl)piperazine
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Stage #1: 1-benzyl-4-(2-hydroxyethyl)piperazine With triphenylphosphine; diethylazodicarboxylate In tetrahydrofuran at 20℃; for 0.333333h; Mitsunobu Displacement; Stage #2: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt In tetrahydrofuran at 60℃; | 5.7% |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
2-bromoethanol
Conditions | Yield |
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Stage #1: 1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt With potassium carbonate In tetrahydrofuran; water for 0.5h; Stage #2: 2-bromoethanol In tetrahydrofuran; water at 20℃; for 24h; |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C 3: potassium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: N,N-dimethyl-formamide / 20 °C 2: hydrogenchloride / dichloromethane; 1,4-dioxane / 3 h / 20 °C 3: potassium carbonate / N,N-dimethyl-formamide / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 2 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 3 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: phosphorus trichloride / N,N-dimethyl-formamide; acetone / 2.16 h / 0 - 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 3 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 60 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 4 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 60 °C 4: hydrogenchloride / water; 1,4-dioxane / 2 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 3 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 4 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C 4: toluene-4-sulfonic acid / 1,4-dioxane; methanol / 16 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 5 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C 4: toluene-4-sulfonic acid / 1,4-dioxane; methanol / 16 h / 20 °C 5: toluene-4-sulfonic acid / 1,4-dioxane; m-xylene / 16 h / Molecular sieve; Reflux View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 6 steps 1: acetic acid / N,N-dimethyl-formamide / 20 °C 2: potassium carbonate / water / 24 h / 20 °C 3: triethylamine / N,N-dimethyl-formamide / 16 h / 20 °C 4: toluene-4-sulfonic acid / 1,4-dioxane; methanol / 16 h / 20 °C 5: toluene-4-sulfonic acid / 1,4-dioxane; m-xylene / 16 h / Molecular sieve; Reflux 6: water / 3 h / 20 °C View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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Multi-step reaction with 2 steps 1.1: sodium iodide / N,N-dimethyl-formamide / 64 h / 0 - 20 °C 2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C 2.2: 20 °C / pH 8.5 View Scheme |
1-[[[5-(4-nitrophenyl)-2-furanyl]methylene]amino]-2,4-imidazolidine-dione sodium salt
Conditions | Yield |
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With water In methanol at 20 - 30℃; for 6h; |
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