14663-53-7 Usage
Description
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID, also known as (4-Oxoquinazolin-3(4H)-yl)acetic Acid, is an organic compound with the chemical structure of a quinazoline derivative. It is characterized by its unique molecular structure, which includes a quinazoline ring fused with an acetic acid group. (4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID has garnered interest in the field of biological research due to its potential applications in various industries.
Uses
Used in Pharmaceutical Industry:
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID is used as a key compound in the study of antibiotic formation by Streptomyces echinatus, a genus of bacteria known for producing a wide range of bioactive secondary metabolites, including antibiotics. The compound plays a crucial role in understanding the biosynthetic pathways and mechanisms involved in the production of these antibiotics, which can lead to the development of new and more effective antimicrobial agents.
Used in Research and Development:
In the field of research and development, (4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID serves as an important tool for studying the structure-activity relationships of various quinazoline-based compounds. This knowledge can be applied to the design and synthesis of novel therapeutic agents with improved pharmacological properties, such as enhanced potency, selectivity, and reduced side effects.
Used in Chemical Synthesis:
(4-OXO-4H-QUINAZOLIN-3-YL)-ACETIC ACID can also be utilized as a building block or intermediate in the synthesis of more complex quinazoline-based molecules. These molecules may have potential applications in various industries, such as pharmaceuticals, agrochemicals, and materials science, where they can be used as active ingredients or components in the development of new products.
Check Digit Verification of cas no
The CAS Registry Mumber 14663-53-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,4,6,6 and 3 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 14663-53:
(7*1)+(6*4)+(5*6)+(4*6)+(3*3)+(2*5)+(1*3)=107
107 % 10 = 7
So 14663-53-7 is a valid CAS Registry Number.
InChI:InChI=1/C10H8N2O3/c13-9(14)5-12-6-11-8-4-2-1-3-7(8)10(12)15/h1-4,6H,5H2,(H,13,14)/p-1
14663-53-7Relevant articles and documents
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Hutchings et al.
, p. 19,20 (1952)
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Novel bronchodilatory quinazolines and quinoxalines: Synthesis and biological evaluation
?pulák, Marcel,Pourová, Jana,Vopr?álová, Marie,Miku?ek, Ji?í,Kune?, Ji?í,Vacek, Jan,Ghavre, Mukund,Gathergood, Nicholas,Pour, Milan
, p. 65 - 72 (2014)
A series of heterocyclic derivatives analogous to (-)vasicinone, in which the vasicinone C-ring was replaced with alkyl chain terminated by tertiary amine was prepared. N3, C4-O, C4-S or C4-N were used as the sites of attachment. The 4-[3-(1-piperidyl)propylsulfanyl]derivatives displayed bronchodilatory effect at low micromolar concentrations on isolated rat trachea, and low toxicity both on Balb/c 3T3 mouse fibroblast cells and in mice.
Development of 2-(4-oxoquinazolin-3(4 H)-yl)acetamide derivatives as novel enoyl-acyl carrier protein reductase (InhA) inhibitors for the treatment of tuberculosis
Pedgaonkar, Ganesh S.,Sridevi, Jonnalagadda Padma,Jeankumar, Variam Ullas,Saxena, Shalini,Devi, Parthiban Brindha,Renuka, Janupally,Yogeeswari, Perumal,Sriram, Dharmarajan
, p. 613 - 627 (2015/01/09)
InhA, the enoyl acyl carrier protein reductase of Mycobacterium tuberculosis (MTB) is an attractive target for developing novel anti-tubercular agents. Twenty eight 2-(4-oxoquinazolin-3(4H)-yl)acetamide derivatives were synthesized and evaluated for their in vitro MTB InhA inhibition. Compounds were further evaluated for their in vitro activity against drug sensitive and resistant MTB strains and cytotoxicity against RAW 264.7 cell line. Compounds were docked at the active site of InhA to understand their binding mode and differential scanning fluorimetry was performed to ascertain their protein interaction and stability.
