14665-31-7

Basic information

• Product Name: C90123
• Synonyms: 4-Chloro-5-chlorosulfonylsalicylic acid;C90123
• CAS NO: 14665-31-7
• Molecular Formula: C₇H₄Cl₂O₅S
• Molecular Weight: 271.07466
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 14665-31-7.mol
• Article Data: 4

Chemical Properties

• Melting Point: 181-183 °C
• Boiling Point: 458.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.819±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 1.00±0.10(Predicted)
• CAS DataBase Reference: C90123(CAS DataBase Reference)
• NIST Chemistry Reference: C90123(14665-31-7)
• EPA Substance Registry System: C90123(14665-31-7)

Safety Data

• Hazardous Substances Data: 14665-31-7(Hazardous Substances Data)

Usage

Description

C90123, also known as 4-Chloro-5-chlorosulfonyl Salicylic acid, is a chemical compound with pale yellow to pale grey solid properties. It is primarily used in the synthesis of various pharmaceutical agents due to its unique chemical structure and reactivity.

Uses

Used in Pharmaceutical Industry:
C90123 is used as a key intermediate in the synthesis of Xipamide (X745150), a diuretic agent. It plays a crucial role in the development of this medication, which is utilized for the treatment of edema and hypertension.
Additionally, due to its chemical properties, C90123 may have potential applications in other industries, such as chemical synthesis or material science, where its unique properties can be exploited for specific purposes.

Upstream product

• 5106-98-9 4-chlorosalicylic acid 

Downstream Products

• 328553-76-0 3-nitro-4-chloro-5-chlorosulfonylsalicylic acid 
• 328553-78-2 3-nitro-4-chloro-5-sulfamoylsalicylic acid chloroanhydride 
• 328553-79-3 3-amino-4-chloro-5-sulfamoylsalicylic acid ethyl ester 
• 55691-09-3 3-nitro-4-chloro-5-sulfamoylsalicylic acid 
• 312942-46-4 3-nitro-4-chloro-5-sulfamoylsalicylic acid ethyl ester 
• 5022-52-6 4-Chlor-3-nitro-salicylsaeure 
• 1610830-34-6 propyl 4-chloro-2-propoxy-5-(pyrrolidine-1-sulfonyl)benzoate 
• 1044911-81-0 ethyl 4-chloro-2-ethoxy-5-(pyrrolidine-1-sulfonyl)benzoate 
• 1610830-33-5 4-chloro-2-hydroxy-5-(pyrrolidine-1-sulfonyl)benzoic acid 

Relevant articles and documents

Novel Imidazolines as dual inhibitors of MDM2 and MDMX

Disclosed are compounds of Formula I or pharmaceutically acceptable salts thereof, wherein X1, X2, X3, R1, R2 and R3 are as described in this application, and methods of using the compounds

Structure activity relationship for derivatives of xipamide (4 chloro 5 sulfamoyl 2',6' salicyloxylidide)

The synthesis of various derivatives of 4 chlorosalicylic acid substituted in position 5 is described. The evaluation of their diuretic potency on the rat showed 4 chloro 5 sulfamoyl 2',6' salicyloxylidide (BE 1293, xipamide, 'Aquaphor') as the most effective. The normal urinary volume is increased 10 fold by an oral dose of 100 mg/kg body weight. All changes in the molecular structure of xipamide, even acetylation, the introduction of a second sulfamoyl group or the exchange of the sulfonic group for the carbonyl group lead to a decrease in activity.