14678-05-8

Basic information

• Product Name: isoxazol-5-amine
• Synonyms: isoxazol-5-amine;5-Isoxazolamine(9CI);Einecs 238-720-4;Isoxazol-5-ylamine;5-Amino-1,2-oxazole, Isoxazol-5-amine;1,2-Oxazol-5-amine
• CAS NO: 14678-05-8
• Molecular Formula: C₃H₄N₂O
• Molecular Weight: 84.07666
• EINECS: 238-720-4
• Product Categories: ISOXAZOLE;Benzofurans
• Mol File: 14678-05-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 75-77 °C
• Boiling Point: 234.652 °C at 760 mmHg
• Flash Point: 95.714 °C
• Appearance: /
• Density: 1.241 g/cm³
• Vapor Pressure: 0.0523mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: 2-8°C(protect from light)
• PKA: -1.23±0.50(Predicted)
• CAS DataBase Reference: isoxazol-5-amine(CAS DataBase Reference)
• NIST Chemistry Reference: isoxazol-5-amine(14678-05-8)
• EPA Substance Registry System: isoxazol-5-amine(14678-05-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 14678-05-8(Hazardous Substances Data)

Usage

General Description

Isoxazol-5-amine is a chemical compound with the molecular formula C3H4N2O. It belongs to the class of isoxazoles, which are five-membered heterocyclic compounds containing an oxygen and nitrogen atom in the ring. Isoxazol-5-amine is a versatile building block in organic synthesis, often used as a precursor for the preparation of various pharmaceuticals, agrochemicals, and other fine chemicals. It can also act as a ligand in coordination chemistry, forming complexes with transition metals. Furthermore, isoxazol-5-amine has been studied for its potential biological activities, including as antimicrobial, anti-inflammatory, and antitumor agents. Due to its structural and chemical properties, isoxazol-5-amine holds significant importance in the fields of medicinal and synthetic chemistry.

InChI:InChI=1/C3H4N2O/c4-3-1-2-5-6-3/h1-2H,4H2

Upstream product

• 7341-96-0 2-propynamide 
• 60838-50-8 3-methoxy-2-propenenitrile 
• 7803-49-8 hydroxylamine 
• 1070-71-9 propiolonitrile 

Downstream Products

• 501921-81-9 C₂₀H₁₄ClN₃O₃ 
• 1450920-98-5 4-(2-cyano-4-(trifluoromethyl)phenyl)-N-(isoxazol-5-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide 

Relevant articles and documents

AMIDE COMPOUND

There is provided a FAAH inhibitor and a prophylactic or therapeutic agent for cerebrovascular disorders or sleep disorders comprising it. The prophylactic or therapeutic agent comprises a compound of the formula (I0): wherein Z is oxygen or sulfur; R1 is aryl which may be substituted, or a heterocyclic group which may be substituted; R1a is a hydrogen atom, a hydrocarbon group which may be substituted, hydroxyl, etc.; R2 is piperidin-1,4-diyl which may be substituted, or piperazin-1,4-diyl which may be substituted; R3 is a group formed by eliminating two hydrogen atoms from a 5-membered aromatic heterocyclic group having 1 to 3 heteroatoms selected from nitrogen, oxygen and sulfur, which may be further substituted, -CO-, etc.; and R4 is a hydrocarbon group which may be substituted, or a heterocyclic group which may be substituted; or a salt thereof.

Reactions of N,N-bis(siloxy)enamines with trimethylsilyl cyanide: Aliphatic nitro compounds as convenient precursors of 5-aminoisoxazoles

A convenient procedure was developed for the synthesis of 5-aminoisoxazoles by the consecutive double silylation and cyanation of aliphatic nitro compounds.