147065-06-3

Basic information

• Product Name: 4-Nitro-D-phenylalanine hydrochloride
• Synonyms: 4-Nitro-D-phenylalanine hydrochloride;(R)-4-Nitrophenylalanine Hydrochloride Salt;H-D-Phe(4-NO2)-OH.HCl;4-NO2-D-phe.hcl.h2o;4-NO2-D-phe.hcl
• CAS NO: 147065-06-3
• Molecular Formula: C9H10N2O4.ClH
• Molecular Weight: 246.649
• Mol File: 147065-06-3.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 435.5 °C at 760 mmHg
• Flash Point: 217.2 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-Nitro-D-phenylalanine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Nitro-D-phenylalanine hydrochloride(147065-06-3)
• EPA Substance Registry System: 4-Nitro-D-phenylalanine hydrochloride(147065-06-3)

Safety Data

• Hazardous Substances Data: 147065-06-3(Hazardous Substances Data)

Usage

General Description

4-Nitro-D-phenylalanine hydrochloride is a chemical compound primarily used in the field of scientific research. It belongs to the class of organic compounds known as d-alpha-amino acids, which are alpha amino acids where the amino group is on the alpha-carbon and the stereochemistry is D. This substance appears as a white solid and is soluble in water. As a derivative of the naturally occurring amino acid phenylalanine, it can be involved in various chemical and biochemical reactions under controlled conditions. However, it should be handled with care due to its reactivity and potential hazards.

Upstream product

• 6265-87-8 2-acetylamino-2-(4-nitrobenzyl)malonic acid diethyl ester 
• 20877-15-0 ethyl 2-acetylamino-2-cyano-3-(4-nitrophenyl)propanoate 
• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 76684-78-1 N-Benzoyl-p-nitro-D-phenylalanine 
• 93634-58-3 2-benzoylamino-3-(4-nitrophenyl)acrylic acid 
• 555-16-8 4-nitrobenzaldehdye 
• 36097-39-9 (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 88546-12-7 methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate 

Downstream Products

• 108460-09-9 N_α-(2-Naphthylsulfonylglycyl)-4-nitro-phenylalaninpiperidid 
• 109273-47-4 N_α-(2-Naphthylsulfonylglycyl)-4-amino-phenylalaninpiperididhydrochlorid 
• 108460-12-4 N_α-(2-Naphthylsulfonylglycyl)-4-amino-phenylalaninpiperidid 
• 127090-51-1 2-acetylamino-3-(4-nitro-phenyl)-propionic acid methyl ester 
• 1575605-44-5 butyl 2-acetylamino-3-(4-nitrophenyl)propanoate 
• 1575618-78-8 allyl 2-acetylamino-3-(4-nitrophenyl)propanoate 
• 1575603-81-4 butyl 2-acetylamino-3-(4-nitrophenyl)propanoate 
• 36097-39-9 (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 88546-12-7 methyl (R)-2-acetamido-3-(4-nitrophenyl)propanoate 
• 1575603-84-7 allyl 2-acetylamino-3-(4-nitrophenyl)propanoate 
• 17193-40-7 (+)-Methyl 2-amino-3-(4-nitrophenyl)propionate hydrochloride 
• 1575604-75-9 C₁₃H₁₈N₂O₄*ClH 
• 1575605-05-8 C₁₂H₁₄N₂O₄*ClH 
• 93942-39-3 C₂₃H₂₄Cl₂N₂O₄ 

Relevant articles and documents

Melphalan intermediate and preparation method thereof

The invention discloses a Melphalan intermediate and a preparation method thereof. The Melphalan intermediate is prepared by acidifying a compound p-nitrobenzaldehyde under the action of methanol, a hydrochloric acid solvent, etc. The preparation method has a route with mild reaction conditions, is higher than an existing preparation method in yield, is economical and effective, and is suitable for large-scale industrial production. The synthesis route is as shown in the description.

Anthranilic acid based CCK1 receptor antagonists: Preliminary investigation on their second "touch point"

In this phase of structure-affinity relationship study of VL-0395, a new anthranilic acid based CCK1 selective antagonist, we propose a series of unnatural aminoacidic derivatives. The result of this work is the identification of a new CCK ligand, which possesses an affinity (IC50 = 35 nm) one order of magnitude greater than the lead and, as a general rule, it points out how the hypothesized receptorial pocket which accommodates the Phe residue allows much more structural modification than that interacting with the N-terminal group. Hence, the modification of the C-terminal pharmacophoric group of our lead VL-0395 can not only enhance the affinity of anthranilic acid derivatives but can modulate the selectivity for one CCK receptor subtype or afford mixed antagonists.