147151-82-4

Basic information

• Product Name: (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione
• Synonyms: (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione
• CAS NO: 147151-82-4
• Molecular Formula: C29H35 F O4
• Molecular Weight: 466.58
• Mol File: 147151-82-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione(CAS DataBase Reference)
• NIST Chemistry Reference: (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione(147151-82-4)
• EPA Substance Registry System: (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione(147151-82-4)

Safety Data

• Hazardous Substances Data: 147151-82-4(Hazardous Substances Data)

Usage

Description

(1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione is a chemical compound that is a derivative of pregnenolone, a naturally occurring hormone in the body that is involved in the production of other steroid hormones such as estrogen and testosterone. (1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione contains a fluorophenyl group and an ethylenedioxy group attached to the pregnenolone structure. It may have potential pharmacological properties due to its structural modification.
Used in Pharmaceutical Industry:
(1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione is used as a research compound for the development of drugs targeting hormone regulation and reproductive health. Its structural modification may provide unique pharmacological properties that can be utilized in the treatment of related conditions.
Used in Research Applications:
(1'-(4-fluorophenyl)(ethylenedioxy))pregn-4-ene-3,20-dione is used as a research tool to study the effects of structural modifications on the pharmacological properties of pregnenolone and its derivatives. Further studies and clinical trials are needed to determine the specific effects and potential applications of this compound in various therapeutic areas.

Upstream product

• 595-77-7 R-16α,17-dihydroxy-pregn-4-ene-3,20-dione 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1096-38-4 16-dehydroprogesterone 

Relevant articles and documents

Progestin 16α,17α-dioxolane ketals as molecular probes for the progesterone receptor: Synthesis, binding affinity, and photochemical evaluation

Chemical probes for steroid receptors have proven useful in providing molecular details about important hormone-receptor interactions. A series of progestin 16α,17α-dioxolane ketals of acetophenone or substituted acetophenones that bind to the progesterone receptor (PgR) with comparable or higher affinities than the natural ligand, progesterone, have been prepared and evaluated as potential in vitro and in vivo probes for the progesterone receptor. p-Azidoacetophenone ketal 6, the tetrafluoro analog 8, and the p- (benzoyl)acetophenone ketal 9 demonstrate the required combination of high relative binding affinity (RBA) (6 = 15%, 8 = 14%, 9 = 6.6%, progesterone = 13%, R5020 = 100%) and photoinactivation efficiency (6 = 80%, 8 = 77%, 9 = 29% at 30 min) required for potential photoaffinity labeling reagents for the PgR. The synthesis of azide 6 has been modified to accommodate a palladium- catalyzed tritium gas hydrogenolysis of an iodoaryl precursor in the final stage of the synthetic sequence; this procedure has been verified by hydrogenation. In addition, the progestin p-fluoroacetophenone ketal 10 was selected for preparation in fluorine-18-labeled form, on the basis of its high affinity for the PgR (RBA = 53%). Fluorine-18-labeled progestins may be evaluated as potential diagnostic imaging agents for PgR-positive breast tumors. The radiochemical syntheses and further biochemical results with the fluorine-18-labeled ketal 10 and the tritium-labeled aryl azide 6 will be presented in an accompanying paper and elsewhere.