147189-93-3

Basic information

• Product Name: (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one
• Synonyms: (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one
• CAS NO: 147189-93-3
• Molecular Weight: 231.078
• Mol File: 147189-93-3.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one(147189-93-3)
• EPA Substance Registry System: (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one(147189-93-3)

Safety Data

• Hazardous Substances Data: 147189-93-3(Hazardous Substances Data)

Upstream product

• 50597-19-8 3-(3,4-dichlorobenzoyl)-propionic acid 
• 256474-26-7 (S)-(+)-(3,4-Dichlorophenyl)oxirane 
• 105-53-3 diethyl malonate 
• 22660-10-2 4-(3,4-dichlorophenyl)-4-oxo-2-butenoic acid 
• 2642-63-9 3',4'-dichloroacetophenone 

Downstream Products

• 79560-18-2 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid 

Relevant articles and documents

Palladium/Zinc Co-Catalyzed Asymmetric Hydrogenation of γ-Keto Carboxylic Acids

A palladium-catalyzed asymmetric hydrogenation of levulinic acid has been successful developed by using Zn(OTf)2 as co-catalyst. The present method not only has provided a strategy in the palladium-catalyzed asymmetric hydrogenation of ketone, but also allowed the preparation of a wide range of chiral γ-valerolactones in good yields with excellent enantioselectivities.

Asymmetric hydrogenation reaction γ - or δ - ketonato compound (by machine translation)

The invention relates to the field, of organic chemistry, specifically γ - or δ - keto acid compound asymmetric hydrogenation reaction, reaction formula as follows : Wherein R is H,C. 1 - C6 An alkyl or halogen, is R 1 - 5 in number of substituents . wherein n is 1 or 2;Cat. is a chiral spiro pyrimidyl phosphine ligand iridium complex . and γ - or δ - keto acid compound is subjected to an internal esterification reaction to further prepare a lactone compound. (by machine translation)

Chemo-enzymatic synthesis of (R)- and (S)-3,4-dichlorophenylbutanolide intermediate in the synthesis of sertraline

3,4-Dichlorophenacylchloride was reduced with whole cell biocatalysts to give the (R)- or (S)-chlorohydrine in high yields and good to high enantiomeric excess. Yields and enantiomeric purity of the (S)-enantiomer were increased to 95 and >98%, respective