147197-81-7

Basic information

• Product Name: 7-fluoro-2-phenyl-4-quinolone
• Synonyms: 7-fluoro-2-phenyl-4-quinolone
• CAS NO: 147197-81-7
• Molecular Formula: C₁₅H₁₀FNO
• Molecular Weight: 239.24
• Mol File: 147197-81-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 386°Cat760mmHg
• Flash Point: 187.2°C
• Appearance: /
• Density: 1.269g/cm³
• Vapor Pressure: 3.66E-06mmHg at 25°C
• Refractive Index: 1.616
• CAS DataBase Reference: 7-fluoro-2-phenyl-4-quinolone(CAS DataBase Reference)
• NIST Chemistry Reference: 7-fluoro-2-phenyl-4-quinolone(147197-81-7)
• EPA Substance Registry System: 7-fluoro-2-phenyl-4-quinolone(147197-81-7)

Safety Data

• Hazardous Substances Data: 147197-81-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C15H10FNO/c16-11-6-7-12-14(8-11)17-13(9-15(12)18)10-4-2-1-3-5-10/h1-9H,(H,17,18)

Upstream product

• 1006-39-9 1-(2-bromo-4-fluorophenyl)ethanone 
• 55-21-0 benzamide 
• 372-19-0 meta-fluoroaniline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 159305-15-4 1-(2-Amino-4-fluorophenyl)ethanone 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 255724-71-1 5-fluoro-2-iodoaniline 
• 13939-06-5 molybdenum hexacarbonyl 
• 3446-58-0 3-oxo-3-phenylpropanamide 

Downstream Products

• 954225-43-5 4-chloro-7-fluoro-2-phenylquinoline 

Relevant articles and documents

Carbonylative Sonogashira annulation sequence: One-pot synthesis of 4-quinolone and 4H-chromen-4-one derivatives

Carbonylative Sonogashira annulation sequence for one pot synthesis of 4-quinolone and 4H-chromen-4-one has been developed in presence of Pd-NHC catalyst. Substituted 2-iodoaniline and 2-iodophenol independently underwent in the carbonylative Sonogashira

2-aryl-4-quinolone derivative as well as preparation method and application thereof

The invention discloses a 2-aryl-4-quinolone derivative as well as a preparation method and an application thereof. The 2-aryl-4-quinolone derivative has the structure shown in formula (I) in the description, wherein R1 is independently selected from one or more of H, C1-C5 alkyl, halogen or C1-C5 alkoxy, and R2 is independently selected from one or more of H, C1-C5 alkyl, CF3, halogen or C1-C5 alkoxy. Test results show that the 2-aryl-4-quinolone derivative has good antibacterial activity and can be used as an antibacterial agent.

Transition-metal-free oxidative intermolecular cyclization reaction: Synthesis of 2-aryl-4-quinolones

Herein, a novel and efficient intermolecular cyclization of 2-aminoacetophenones with aldehydes was developed for the synthesis of 2-aryl-4-quinolones through C-C and C-N bond formation. Mild conditions, good functional group tolerance, and substrates without prefunctionalization make this protocol practical, and this strategy will stimulate keen interest in fields of chemistry and biology.