147199-39-1 Usage
Description
(S)-N-Demethyl Dapoxetine, also known as (S)-metabolite of Dapoxetine (D185700), is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It is derived from Dapoxetine, a medication primarily used to treat premature ejaculation in men. The (S)-enantiomer of Dapoxetine has been found to possess antidepressant properties, making it a potential candidate for the treatment of various mood disorders.
Uses
Used in Pharmaceutical Industry:
(S)-N-Demethyl Dapoxetine is used as an antidepressant for the treatment of mood disorders. Its selective serotonin reuptake inhibition property helps regulate serotonin levels in the brain, which is crucial for maintaining a balanced mood and emotional well-being.
Used in Research and Development:
(S)-N-Demethyl Dapoxetine is also used in the research and development of new medications for the treatment of mood disorders. Its unique properties as a selective serotonin reuptake inhibitor make it a valuable compound for studying the mechanisms of action and potential therapeutic applications in the field of psychiatry and neuroscience.
Check Digit Verification of cas no
The CAS Registry Mumber 147199-39-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,1,9 and 9 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 147199-39:
(8*1)+(7*4)+(6*7)+(5*1)+(4*9)+(3*9)+(2*3)+(1*9)=161
161 % 10 = 1
So 147199-39-1 is a valid CAS Registry Number.
147199-39-1Relevant articles and documents
Highly efficient, enantioselective syntheses of (S)-(+)- and (R)-(-)-dapoxetine starting with 3-phenyl-1-propanol
Kang, Soyeong,Lee, Hyeon-Kyu
supporting information; experimental part, p. 237 - 240 (2010/04/06)
(Chemical Equation Presented) A highly efficient, enantioselective sequence has been developed for the synthesis of (S)- and (R)-dapoxetine. The pathways involve the intermediacy of the 6-membered-ring sulfamate esters 4, which were generated by Du Bois asymmetric C-Hamination reactions of the prochiral sulfamate 3, catalyzed by the chiral dirhodium(II) complexes. During the course of our research, the absolute configuration of the enantiomer of 4-pheny[1,2,3]oxathiazinane 2,2-dioxide (4r), prepared by the Du Bois asymmetric C-H amination reaction of 3 and the Rh2(S-nap)4 catalyst, is determined to be R and not S as was originally reported.
