147245-92-9

Basic information

• Product Name: Glatiramer acetate
• Synonyms: GLATIRAMER ACETATE;l-glutamic acid polymer with l-alanine, l-lysine and l-tyrosine, acetate (salt);511: PN: WO2010103292 PAGE: 64 claiMed sequence;L-Alanine polyMer with L-GlutaMic Acid L-Lysine L-Tyrosine Acetate;L-GlutaMic Acid peptide with L-Alanine L-Lysine L-Tyrosine Acetate Salt;L-Tyrosine polyMer with L-Alanine L-GlutaMic Acid L-Lysine Acetate;ProtiraMer;GaltiraMer acetate
• CAS NO: 147245-92-9
• Molecular Formula: C25H45N5O13
• Molecular Weight: 623.6505
• EINECS: 1592732-453-0
• Product Categories: Amino Acids & Derivatives;Intermediates & Fine Chemicals;Peptides;Pharmaceuticals;API
• Mol File: 147245-92-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 385.2oC at 760mmHg
• Flash Point: 186.7oC
• Appearance: /
• Vapor Pressure: 1.27E-06mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: Methanol (Slightly), Water (Slightly)
• CAS DataBase Reference: Glatiramer acetate(CAS DataBase Reference)
• NIST Chemistry Reference: Glatiramer acetate(147245-92-9)
• EPA Substance Registry System: Glatiramer acetate(147245-92-9)

Safety Data

• Hazardous Substances Data: 147245-92-9(Hazardous Substances Data)

Usage

Description

Source:
Glatiramer acetate is a synthetic compound, and its production involves the polymerization of the mentioned amino acids in a specific molar ratio.
Production Methods:
The synthesis of glatiramer acetate involves the random copolymerization of L-alanine, L-lysine, l-glutamic acid, and L-tyrosine using standard polymerization techniques. The resulting copolymer is then purified and characterized to ensure its quality and consistency.

Uses

Used in Pharmaceutical Industry:
Glatiramer acetate is used as an immunomodulator for the treatment of multiple sclerosis (MS). It functions by modulating the immune system's response to myelin basic protein, which is a component of the myelin sheath that insulates nerve fibers. By altering the immune response, glatiramer acetate helps reduce the frequency and severity of MS relapses.
Used in Multiple Sclerosis Treatment:
Glatiramer acetate is used as a therapeutic agent for patients with relapsing-remitting multiple sclerosis (RRMS). It is administered through subcutaneous injections and has been shown to decrease the number of relapses and slow the progression of physical disability in RRMS patients.
Brand Name:
Copaxone (Teva) is the brand name under which glatiramer acetate is marketed. It is available in pre-filled syringes and auto-injectors for the convenience of patients and healthcare providers.

Originator

Copaxone,Teva Pharmaceuticals,Israel

Manufacturing Process

Glatiramer Acetate is water soluble copolypeptide with molecular weight 15,000-25,000. Copolymer is prepared by copolymerization of the N-carboxyanhydrides of tyrosine, alanine, lysine, and glutamic acid. The polymerisation was carried out at ambient temperature in anhydrous dioxane with diethylamine as initiator. Glatiramer Acetate have the ratio alanin:glutamic acid:lysine:tyrosine = 1:6:4.54:2.

Clinical Use

Immunomodulating drug: Treatment for patients at a high risk of developing multiple sclerosis and for reduction in relapses in ambulatory patients

Drug interactions

Potentially hazardous interactions with other drugs None known

Metabolism

A substantial fraction of a subcutaneous dose of glatiramer is believed to be hydrolysed locally. Some of the injected dose is also presumed to enter the lymphatic system, either intact or partially hydrolysed.

InChI:InChI=1/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2.C2H4O2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6;1-2(3)4/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6);1H3,(H,3,4)/t8-;5-;3-;2-;/m0000./s1