147248-14-4

Basic information

• Product Name: phenyl(p-tolyl)cyanamide
• Synonyms: phenyl(p-tolyl)cyanamide
• CAS NO: 147248-14-4
• Molecular Weight: 208.263
• Mol File: 147248-14-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: phenyl(p-tolyl)cyanamide(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl(p-tolyl)cyanamide(147248-14-4)
• EPA Substance Registry System: phenyl(p-tolyl)cyanamide(147248-14-4)

Safety Data

• Hazardous Substances Data: 147248-14-4(Hazardous Substances Data)

Upstream product

• 106-49-0 p-toluidine 
• 58109-40-3 diphenyliodonium hexafluorophosphate 
• 10532-64-6 N-(4-methylphenyl)cyanamide 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 147248-13-3 N-Phenyl-N-(para-tolyl)urea 

Relevant articles and documents

Transition-metal free N-arylation of cyanamides by diaryliodonium triflates in aqueous media

An operationally simple protocol is established for the synthesis of disubstituted cyanamides through the transition-metal free N-arylation of cyanamides by diaryliodonium triflates in aqueous media. Both alkyl and aryl cyanamides are well compatible with the mild reaction conditions. The one-pot synthesis of ureas is also possible through sequential arylation and hydrolysis of cyanamides, diaryliodonium triflates and H2O with good yields.

N-SUBSTITUTED HETEROCYCLIC DERIVATIVES USEFUL IN THE TREATMENT OF CARDIOVASCULAR DISORDERS

The present invention relates to N-substituted heterocyclic derivatives of formula: STR1 processes for their preparation, and pharmaceutical compositions which contain them. The compounds according to the invention are non-peptide compounds which oppose the action of angiotensin II. The compounds according to the invention are thus useful in the treatment of cardiovascular disorders such as hypertension and heart failure.