147539-41-1

Basic information

• Product Name: 1-Boc-4-Methylaminopiperidine
• Synonyms: N-BOC-4-METHYLAMINOPIERIDINE;N-BOC-4-METHYLAMINOPIPERIDINE;N-BOC-4-N-METHYLAMINO PIPERIDINE;tert-butyl 4-(methylamino)piperidine-1-carboxylate;BUTTPARK 90\06-11;1-N-BOC-4-(METHYLAMINO)PIPERIDINE;1-BOC-4-METHYLAMINOPIPERIDINE;4-N-METHYLAMINO-1-BOC-PIPERIDINE
• CAS NO: 147539-41-1
• Molecular Formula: C₁₁H₂₂N₂O₂
• Molecular Weight: 214.3
• Product Categories: pharmacetical;Piperidine
• Mol File: 147539-41-1.mol
• Article Data: 37

Chemical Properties

• Boiling Point: 289.003 °C at 760 mmHg
• Flash Point: >110℃
• Appearance: /
• Density: 1.005 g/mL at 25 °C
• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: n20/D1.468
• Storage Temp.: Room temperature.
• PKA: 10.19±0.20(Predicted)
• CAS DataBase Reference: 1-Boc-4-Methylaminopiperidine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Boc-4-Methylaminopiperidine(147539-41-1)
• EPA Substance Registry System: 1-Boc-4-Methylaminopiperidine(147539-41-1)

Safety Data

• Hazard Codes: Xi,N,T
• Statements: 36/37/38-50-25
• Safety Statements: 26-61-45-36/37/39
• RIDADR: 2810
• WGK Germany: 3
• F: 10-34
• HazardClass: 6.1
• PackingGroup: Ⅲ
• Hazardous Substances Data: 147539-41-1(Hazardous Substances Data)

Usage

Description

1-Boc-4-Methylaminopiperidine, also known as 1-(tert-butoxycarbonyl)-4-methylaminopiperidine, is an organic compound that serves as a crucial intermediate in the synthesis of various pharmaceuticals and chemicals. It is a colorless liquid with unique chemical properties that make it valuable in the development of new compounds and drugs.

Uses

1. Used in Organic Chemical Synthesis:
1-Boc-4-Methylaminopiperidine is used as an organic chemical synthesis intermediate for the production of various pharmaceuticals and chemicals. Its unique structure allows for the creation of a wide range of compounds with diverse applications.
2. Used in Pharmaceutical Industry:
a) As a Key Intermediate for Antibacterial Agents:
1-Boc-4-Methylaminopiperidine is a derivative of 3-Methylaminopiperidine Dihydrochloride, which is a key intermediate for the synthesis of the antibacterial agent balofloxacin. This makes it an essential component in the development of new antibiotics to combat bacterial infections.
b) In the Development of New Drugs:
With its versatile chemical properties, 1-Boc-4-Methylaminopiperidine can be used in the pharmaceutical industry to develop new drugs with potential applications in various therapeutic areas, such as pain management, central nervous system disorders, and cardiovascular diseases.

InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-9(12-4)6-8-13/h9,12H,5-8H2,1-4H3

Upstream product

• 301220-70-2 4-(N-(2-phenylethyl)amino)-1-(tert-butoxycarbonyl)piperidine 
• 593-51-1 methylamine hydrochloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 74-89-5 methylamine 
• 847039-05-8 4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 56553-60-7 sodium tris(acetoxy)borohydride 
• 107-06-2 1,2-dichloro-ethane 
• 24424-99-5 di-tert-butyl dicarbonate 
• 7144-05-0 4-Aminomethylpiperidine 
• 191212-86-9 tert-butyl 4-(N-benzyl-N-methylamino)piperidine-1-carboxylate 
• 546-68-9 titanium(IV) isopropylate 

Downstream Products

• 278793-51-4 C₃₃H₃₅Cl₃N₆O₄S 
• 197727-57-4 4-(acetyl-methyl-amino)-piperidine-1-carboxylic acid tert-butyl ester 
• 618429-73-5 4-[(2S-benzyloxycarbonylamino-3,3-dimethylbutyryl)methylamino]piperidine-1-carboxylic acid tert-butyl ester 
• 847039-05-8 4-(((benzyloxy)carbonyl)(methyl)amino)piperidine-1-carboxylic acid tert-butyl ester 
• 301232-33-7 4-(N-(N-(4-nitrobenzyl)carbamoyl)-N-methylamino)-piperidine trifluoroacetate 
• 264904-01-0 2-(4-Amino-2,3,5,6-tetramethylanilino)-N-methyl-N-(4-piperidinyl)acetamide 
• 264905-31-9 2-(4-Amino-2,3,5-trimethylphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 
• 264904-14-5 2-(3-Amino-2,4,6-trimethylanilino)-N-methyl-N-(4-piperidinyl)acetamide 
• 264903-93-7 2-(4-Amino-2,3,5-trimethylphenoxy)-N-methyl-N-(4-piperidinyl)propamide 
• 264903-95-9 2-(2-Amino-4,6-dimethylphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 
• 264903-96-0 2-(4-Amino-2,3,6-trimethylphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 
• 264903-97-1 2-(5-Amino-2-methoxyphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 
• 264904-07-6 2-(4-Amino-2-chloro-3,5,6-trimethylphenoxy)-N-methyl-N-(4-piperidinyl)acetamide 
• 264904-10-1 2-(4-Amino-2,3,5,6-tetramethyl-N-methylanilino)-N-methyl-N-(4-piperidinyl)acetamide 

Relevant articles and documents

Synthesis of N,N-dialkyl-1-(2-alkylthiopyrimidin-4-yl)piperidin- 4-amines as potential heat shock protein inhibitors

A new efficient method for synthesizing promising heat shock protein inhibitors, N,N-dialkyl- 1-(2-alkylthiopyrimidin-4-yl)piperidin-4-amines, by the reaction of 2-alkyl-4-chlorothiouracils with 4-(N-alkyl-N-methylamino)piperidines was developed. 2-Alkyl-4-chlorothiouracils were synthesized by alkylation of 2-thiouracil with alkyl iodides and subsequent treatment of the intermediates with POCl3. 4-(N-Alkyl-N-methylamino)piperidines were prepared by reductive amination of 1-(tert-butoxycarbonyl)-4-piperidinone with methylamine followed by treatment of the intermediate with the appropriate aldehydes.

Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors

A series of anthranilamide derivatives were designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound 12a displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50 = 0.48 μM) than LY2940680 (IC50 = 0.79 μM).

SMO (smoothened) inhibitor containing benzoylpiperidine structure and preparation and application methods thereof

The invention discloses a benzoylpiperidine derivative and preparation and application methods thereof. The benzoylpiperidine derivative is a compound containing N-methyl-N-(1-(2-aminobenzoyl)piperidine-4-yl)amide structure shown as the formula I. The invention also discloses a preparation method of the benzoylpiperidine derivative. The invention also discloses application of the benzoylpiperidinederivative to preparing SMO protein inhibitors as well as application of drug combinations containing the benzoylpiperidine derivative to preparing anti-tumor drugs.