147644-11-9

Basic information

• Product Name: 7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE
• Synonyms: 7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE;AKOS BBS-00006807;4-Bromo-1,2-trimethylenedioxybenzene;7-Bromo-3,4-dihydro-1,5-benzodioxepin, 96%;2H-1,5-Benzodioxepin, 7-broMo-3,4-dihydro-
• CAS NO: 147644-11-9
• Molecular Formula: C₉H₉BrO₂
• Molecular Weight: 229.07
• Mol File: 147644-11-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 82 °C
• Flash Point: 145-148°C/16mm
• Appearance: /
• Density: 1.504g/cm³
• Vapor Pressure: 0.008mmHg at 25°C
• Refractive Index: 1.5790
• CAS DataBase Reference: 7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE(CAS DataBase Reference)
• NIST Chemistry Reference: 7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE(147644-11-9)
• EPA Substance Registry System: 7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE(147644-11-9)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-37/39
• Hazardous Substances Data: 147644-11-9(Hazardous Substances Data)

Usage

General Description

7-BROMO-3,4-DIHYDRO-2H-1,5-BENZODIOXEPINE, also known as brotizolam, is a chemical compound belonging to the benzodiazepine class of psychoactive drugs. It is a sedative-hypnotic substance that is commonly used as a sleeping aid and anxiolytic. Brotizolam works by enhancing the effects of the neurotransmitter gamma-aminobutyric acid (GABA) in the brain, leading to sedative and muscle-relaxant effects. It is typically prescribed for the short-term treatment of severe insomnia and anxiety disorders. Brotizolam is a controlled substance due to its potential for addiction and dependence, and should be used under strict medical supervision.

InChI:InChI=1/C9H9BrO2/c10-7-2-3-8-9(6-7)12-5-1-4-11-8/h2-3,6H,1,4-5H2

Upstream product

• 7216-18-4 3,4-dihydro-2H-benzo[b][1,4]dioxepine 

Downstream Products

• 1187656-80-9 7-(phenylethynyl)-3,4-dihydro-2H-[1,5]benzodioxepin 
• 851958-54-8 (3,4-dihydro-2H-benzo[b][1,4]dioxepin-7-yl)-(3,5-dimethoxy-phenyl)-methanol 

Relevant articles and documents

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1is an optionally substituted 5- to 6-membered ring; the ring A is an optionally substituted 6- to 7-membered ring; the ring B is an optionally substituted benzene ring; n is an integer of 1 or 2; Z is a chemical bond or a divalent group; R2is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, (2) an optionally substituted nitrogen-containing heterocyclic ring group which may contain a sulfur atom or an oxygen atom as ring constituting atoms and wherein a nitrogen atom may form a quaternary ammonium, (3) a group binding through a sulfur atom or (4) a group of the formula: ?wherein k is 0 or 1, and when k is 0, a phosphorus atom may form a phosphonium; and R5and R6are independently an optionally substituted hydrocarbon group, an optionally substituted hydroxy group or an optionally substituted amino group, and R5and R6may bind to each other to form a cyclic group together with the adjacent phosphorus atom, or a salt thereof , which is useful for antagonizing CCR5 and also for the prevention and treatment of infectious disease of HIV.