147795-55-9

Basic information

• Product Name: ethyl 2-cyano-2-(p-tolyl)acetate
• CAS NO: 147795-55-9
• Molecular Weight: 203.241
• Mol File: 147795-55-9.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: ethyl 2-cyano-2-(p-tolyl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-cyano-2-(p-tolyl)acetate(147795-55-9)
• EPA Substance Registry System: ethyl 2-cyano-2-(p-tolyl)acetate(147795-55-9)

Safety Data

• Hazardous Substances Data: 147795-55-9(Hazardous Substances Data)

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 105-58-8 Diethyl carbonate 
• 624-31-7 4-tolyl iodide 
• 105-56-6 ethyl 2-cyanoacetate 
• 106-38-7 para-bromotoluene 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 29148-27-4 diethyl 2-(4-methylphenyl)propane-1,3-dioate 
• 204119-06-2 ethyl α-cyano-α-fluoro-p-tolylacetate 
• 204119-07-3 ethyl (R)-α-cyano-α-fluoro-α-tolyl-acetate 
• 253178-33-5 (+/-)-α-cyano-α-fluoro-p-tolylacetyl chloride 
• 677300-31-1 (S)-α-cyano-α-fluoro-p-tolylacetyl chloride 
• 677300-33-3 (R)-α-cyano-α-fluoro-p-tolylacetyl chloride 
• 253178-32-4 (+/-)-α-cyano-α-fluoro-p-tolylacetic acid 

Relevant articles and documents

Copper-Catalyzed Reaction of Aryl Iodides with Active Methylene Compounds

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AlCl3 catalyzed coupling of: N-benzylic sulfonamides with 2-substituted cyanoacetates through carbon-nitrogen bond cleavage

A new cross-coupling reaction of N-benzylic sulfonamides with 2-substituted cyanoacetates for the synthesis of 2-substituted benzylbenzene was reported. In the presence of AlCl3, a broad range of N-benzylic sulfonamides reacted smoothly with 2-substituted cyanoacetates to afford structurally diverse benzylbenzenes in moderate to excellent yields. The conversion could be enlarged to gram-scale efficiently. The practicability of this approach was further manifested in the synthesis of a related bioactive agent with high anti-inflammatory activity.

Metal-free photochemical aromatic perfluoroalkylation of α-cyano arylacetates

We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α-cyano arylacetates. This metal-free approach, which occurs at ambient temperature and under visible-light irradiation, is driven by t

An efficient and mild CuI/L-proline-catalyzed arylation of acetylacetone or ethyl cyanoacetate

The coupling reaction of aryl iodides with acetylacetone or ethyl cyanoacetate under catalysis of CuI/L-proline works at relatively mild conditions to provide 3-aryl-2, 4-pentanediones and α-aryl cyanoacetates in moderate to good yields. Georg Thieme Verlag Stuttgart.