14811-73-5Relevant articles and documents
Amberlyst A 21 as new and efficient surface catalyst for the cleavage of 2-nitrocycloalkanones
Ballini,Petrini,Polzonetti
, p. 355 - 357 (1992)
Ring cleavage of 2-Nitrocycloalkanones with methanol/Amberlyst A 21 gave methyl ω-nitroalkanoates, O2NCH2(CH2)(n)CO2Me where n = 3-6, 8-10,13, in high yield. Subsequent Nef reaction gave the corresponding ω-oxo compounds which were isolated, in the case of methyl 7-oxoheptanoate and methyl 8-oxooctanoate only, or reduced directly with sodium borohydride to give ω-hydroxyalkanoates. A new formal synthesis of exaltolide (15-pentadecanolide) is also reported.
Ozone: A versatile reagent for solid phase synthesis
Sylvain, Catherine,Wagner, Alain,Mioskowski, Charles
, p. 1043 - 1044 (1997)
Ozone is a versatile reagent which is well adapted to solid phase synthesis: terminal double bonds can he efficiently converted into alcohols, aldehydes or carboxylic acids depending on the reaction conditions.
A ROUTE TO LARGE CARBOCYCLES USING AN ALICYCLIC CLAISEN REARRANGEMENT.
Cameron, Andrew G.,Knight, David W.
, p. 5455 - 5458 (1982)
A potentially general route to large carbocycles is described involving a Claisen rearrangement of silyl enolates derived from appropriate unsaturated macrolides.
A new simple synthesis of a prostanoid synthon
Gokhale,Dalavoy,Prakasa Rao,et al.
, p. 718 - 719 (1974)
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Novel Photooxidation of Alkenes Sensitized by p-Dimethoxybenzene
Bhalerao, Uday T.,Sridhar, Madabhushi
, p. 4341 - 4342 (1993)
Photoexcited p-dimethoxybenzene catalyses oxidative cleavage of various alkenes to corresponding carbonyls in the presence of oxygen.
A General Approach to Intermolecular Olefin Hydroacylation through Light-Induced HAT Initiation: An Efficient Synthesis of Long-Chain Aliphatic Ketones and Functionalized Fatty Acids
Guin, Joyram,Paul, Subhasis
supporting information, p. 4412 - 4419 (2021/02/05)
Herein, an operationally simple, environmentally benign and effective method for intermolecular radical hydroacylation of unactivated substrates by employing photo-induced hydrogen atom transfer (HAT) initiation is described. The use of commercially available and inexpensive photoinitiators (Ph2CO and NHPI) makes the process attractive. The olefin hydroacylation protocol applies to a wide array of substrates bearing numerous functional groups and many complex structural units. The reaction proves to be scalable (up to 5 g). Different functionalized fatty acids, petrochemicals and naturally occurring alkanes can be synthesized with this protocol. A radical chain mechanism is implicated in the process.
DIHYDROOROTIC ACID DEHYDROGENASE INHIBITOR
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Paragraph 0072; 0073; 0074, (2015/04/15)
The present invention provides a novel dihydroorotic acid dehydrogenase inhibitor which is applicable to various diseases. When used as an active ingredient, a compound represented by formula (I): (wherein X represents a halogen atom, R1 represents a hydrogen atom, R2 represents an alkyl group containing 1 to 7 carbon atoms, R3 represents -CHO, and R4 represents -CH2-CH=C(CH3)-R0 (wherein R0 represents an alkyl group containing 1 to 12 carbon atoms which may have a substituent on the terminal carbon and/or on a non-terminal carbon, etc.)), an optical isomer thereof or a pharmaceutically acceptable salt thereof has a high inhibitory effect on dihydroorotic acid dehydrogenase and can be used as an immunosuppressive agent, a therapeutic agent for rheumatism, an anticancer agent, a therapeutic agent for graft rejection, an antiviral agent, an anti-H. pylori agent, a therapeutic agent for diabetes or the like.
NOVEL DIHYDROXYBENZENE DERIVATIVES AND ANTIPROTOZOAL AGENT COMPRISING SAME AS ACTIVE INGREDIENT
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Paragraph 0082-0084, (2013/09/26)
Novel compounds below are useful for preventing or treating diseases caused by protozoans. At least one of a compound represented by Formula (I) (wherein, X represents a hydrogen atom or a halogen atom; R1 represents a hydrogen atom; R2 represents a hydrogen atom or a C1-7 alkyl group; R3 represents -CHO, -C(=O)R5, -COOR5 (wherein R5 represents a C1-7 alkyl group), -CH2OH or -COOH; and R4 represents a C1-16 alkyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), a C2-16 alkenyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s), or a C2-16 alkynyl group having one or more substituents on a terminal carbon atom and/or non-terminal carbon atom(s)), an optical isomer thereof, and a pharmaceutically acceptable salt is used.