148460-02-0Relevant articles and documents
Asymmetric dihydroxylation of aryl allyl ethers
Wang,Zhang,Sharpless
, p. 2267 - 2270 (1993)
Asymmetric dihydroxylation of substituted aryl allyl ethers is described. Para-substituents are shown to favor high enantioselectivity (89-95%ee), while ortho-groups have a deleterious effect (28-63%ee). Four medicinal agents were prepared: guaifenesin (expectorant), mephenesin (muscle relaxant), chlorphenesin (antifungal) and propanolol (β-blocker).