148747-76-6

Basic information

• Product Name: [5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid
• Synonyms: [5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid
• CAS NO: 148747-76-6
• Molecular Weight: 397.363
• Mol File: 148747-76-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: [5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid(148747-76-6)
• EPA Substance Registry System: [5-[(benzyloxycarbonyl)amino]-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl]acetic acid(148747-76-6)

Safety Data

• Hazardous Substances Data: 148747-76-6(Hazardous Substances Data)

Upstream product

• 161488-95-5 <5-<(benzyloxycarbonyl)amino>-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>acetaldehyde dimethyl acetal 
• 161488-94-4 1-(2,2-dimethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1H)-one-5-carboxylic acid 
• 149742-96-1 N-(2,2-dimethoxyethyl)-4-(fluorophenyl)carboxamidine 
• 149742-99-4 methyl 1-(2,2-dimethoxyethyl)-2-(4-fluorophenyl)pyrimidin-6(1H)-one-5-carboxylate 
• 1194-02-1 4-fluorobenzonitrile 
• 148747-75-5 5-benzyloxycarbonylamino-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinylacetaldehyde 

Downstream Products

• 207235-82-3 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-hydroxymethyl-2-phenylethyl]acetamide 
• 207235-80-1 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-[1-[[5-(methoxycarbonyl)benzoxazol-2-yl]hydroxymethyl]-2-phenylethyl]acetamide 
• 148747-77-7 2-<5-<(benzyloxycarbonyl)amino>-6-oxo-2-(4-fluorophenyl)-1,6-dihydro-1-pyrimidinyl>-N-(3,3,3-trifluoro-2-hydroxy-1-isopropylpropyl)acetamide 
• 148747-80-2 2-[2-(4-fluorophenyl)-6-oxo-5-(pyridin-4-ylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 148747-82-4 2-[2-(4-Fluorophenyl)-6-oxo-5-(pyridin-2-ylmethoxycarbonylamino)-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 148747-78-8 2-[5-benzyloxycarbonylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(2-tert-butyldimethylsilyloxy-3,3,3-trifluoro-1-isopropylpropyl)acetamide 
• 1025829-60-0 [1-{[2-(tert-Butyl-dimethyl-silanyloxy)-3,3,3-trifluoro-1-isopropyl-propylcarbamoyl]-methyl}-2-(4-fluoro-phenyl)-6-oxo-1,6-dihydro-pyrimidin-5-yl]-carbamic acid trichloromethyl ester 
• 148747-83-5 {2-(4-Fluoro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl}-carbamic acid pyridin-2-ylmethyl ester 
• 148748-54-3 2-[2-(4-fluorophenyl)-5-(N-trifluoroacetyl-N-methylamino)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3,-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 148747-81-3 {2-(4-Fluoro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-2-hydroxy-1-isopropyl-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl}-carbamic acid pyridin-4-ylmethyl ester 
• 148746-64-9 2-[5-Trifluoroacetylamino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 
• 148747-79-9 2-<5-amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl>-N-<2<(tert-butyldimethylsilyl)oxy>-3,3,3-trifluoro-1-isopropylpropyl>acetamide 
• 154753-62-5 {2-(4-Fluoro-phenyl)-6-oxo-1-[(3,3,3-trifluoro-1-isopropyl-2-oxo-propylcarbamoyl)-methyl]-1,6-dihydro-pyrimidin-5-yl}-carbamic acid methyl ester 
• 154753-63-6 2-[5-amino-2-(4-fluorophenyl)-6-oxo-1,6-dihydro-1-pyrimidinyl]-N-(3,3,3-trifluoro-1-isopropyl-2-oxopropyl)acetamide 

Relevant articles and documents

Heterocyclic amide compounds and medicinal uses thereof

PCT No. PCT/JP97/03839 Sec. 371 Date Apr. 22, 1999 Sec. 102(e) Date Apr. 22, 1999 PCT Filed Oct. 22, 1997 PCT Pub. No. WO98/18794 PCT Pub. Date May 7, 1998A heterocyclic amide compound of the formula (I) wherein each symbol is as defined in the specification, a pharmacologically acceptable salt thereof, a pharmaceutical composition thereof and a pharmaceutical use thereof. The heterocyclic amide compound and a pharmacologically acceptable salt thereof of the present invention have superior inhibitory action on chymase group in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be used for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.

1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase

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Substituted 1,3-diazines as leukocyte elastase inhibitors

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